URAT1 inhibitor 11

Cat. No.: HY-168740: FAQs
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URAT1 inhibitor 11 (Compound 7) is a URAT1 inhibitor with an IC₅₀ value of 0.18 μM. URAT1 inhibitor 11 exhibits potent hypouricemic effects in hyperuricemic zebrafish induced by Potassium oxonate (HY-17511) and Xanthine sodium salt (HY-W017389).

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URAT1 inhibitor 11 Chemical Structure

CAS No. : 2416416-13-0

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Description	URAT1 inhibitor 11 (Compound 7) is a URAT1 inhibitor with an IC₅₀ value of 0.18 μM. URAT1 inhibitor 11 exhibits potent hypouricemic effects in hyperuricemic zebrafish induced by Potassium oxonate (HY-17511) and Xanthine sodium salt (HY-W017389)^[1].
In Vitro	URAT1 inhibitor 11 (60 min) is more stable than Benzbromarone (HY-B1135) in mouse liver microsomes (remaining percentage: 83.2% and 4.5%, respectively)^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. URAT1 inhibitor 11 Related Antibodies
In Vivo	URAT1 inhibitor 11 (0.5 μM) has hypouricemic effects in hyperuricemic zebrafish induced by Potassium oxonate (HY-17511) and Xanthine sodium salt (HY-W017389), with reduced blood uric acid levels ^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	392.35
Formula	C₂₀H₁₆F₄N₂O₂
CAS No.	2416416-13-0
SMILES	OC(CCCN(C1=CC(F)=CC=C1)C2=CC=NC3=CC=C(C(F)(F)F)C=C32)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Hou X, et al. Identification of N-phenyl-N-(quinolin-4-yl) amino carboxylic acids as URAT1 inhibitors with hypouricemic effects. Bioorg Med Chem Lett. 2024 Dec 4;117:130053. [Content Brief]

URAT1 inhibitor 11 Related Classifications

Endocrinology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

URAT1 inhibitor 112416416-13-0URAT1Urate transporter 1SLC22A12HypouricemiaZebrafishUric acidGoutMicrosomesULTHypouricemiaULTInhibitorinhibitorinhibit

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URAT1 inhibitor 11

URAT1 inhibitor 11 Related Antibodies

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