2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. AG 370

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor.

For research use only. We do not sell to patients.

AG 370 Chemical Structure

AG 370 Chemical Structure

CAS No. : 134036-53-6

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Based on 1 publication(s) in Google Scholar

AG 370 Related Antibodies

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Description

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].

IC50 & Target[1]

PDGFR

20 μM (IC50)

In Vitro

AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM)[1][1].
In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor[1][1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AG 370 Related Antibodies
Molecular Weight

259.27

Formula

C15H9N5
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

N#C/C(C#N)=C(N)/C(C#N)=C\C1=CC=C(NC=C2)C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (115.71 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8570 mL 19.2849 mL 38.5698 mL
5 mM 0.7714 mL 3.8570 mL 7.7140 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8570 mL 19.2849 mL 38.5698 mL 96.4246 mL
5 mM 0.7714 mL 3.8570 mL 7.7140 mL 19.2849 mL
10 mM 0.3857 mL 1.9285 mL 3.8570 mL 9.6425 mL
15 mM 0.2571 mL 1.2857 mL 2.5713 mL 6.4283 mL
20 mM 0.1928 mL 0.9642 mL 1.9285 mL 4.8212 mL
25 mM 0.1543 mL 0.7714 mL 1.5428 mL 3.8570 mL
30 mM 0.1286 mL 0.6428 mL 1.2857 mL 3.2142 mL
40 mM 0.0964 mL 0.4821 mL 0.9642 mL 2.4106 mL
50 mM 0.0771 mL 0.3857 mL 0.7714 mL 1.9285 mL
60 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6071 mL
80 mM 0.0482 mL 0.2411 mL 0.4821 mL 1.2053 mL
100 mM 0.0386 mL 0.1928 mL 0.3857 mL 0.9642 mL
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AG 370 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG 370134036-53-6AG370AG-370PDGFRPlatelet-derived growth factor receptormitogenesisautophosphorylationtyrosine phosphorylationInhibitorinhibitorinhibit

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