2. Membrane Transporter/Ion Channel
  3. URAT1
  4. URAT1 inhibitor 10

URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for OAT1 .

For research use only. We do not sell to patients.

URAT1 inhibitor 10 Chemical Structure

URAT1 inhibitor 10 Chemical Structure

CAS No. : 3012586-38-5

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URAT1 inhibitor 10 Related Antibodies

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Description

URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for OAT1 [1].

In Vitro

URAT1 inhibitor 10 shows low cytotoxicity (IC50 > 64 μg/mL) in HepG2 cells[1].
URAT1 inhibitor 10 (5 μM; 30 min) inhibits OAT1 activity in MDCK-hOAT cells (IC50 =9.17 μM)[1].
URAT1 inhibitor 10 (24 h) shows moderate inhibition of IL-6 (IR = 25.6%) in RAW264.7 cells, which may alleviate symptoms associated with MSU crystal-mediated inflammatory cytokines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

URAT1 inhibitor 10 Related Antibodies
In Vivo

URAT1 inhibitor 10 (10 mg/kg; p.o. once a day for 7 days) shows a significant reduction in the activity of serum uric acid (SUA) in a mouse model of hyperuricemia induced by potassium oxybate with a reduction of 53.9%[1].
URAT1 inhibitor 10 (50 mg/kg; p.o.) has a favorable pharmacokinetic profile[1].

Pharmacokinetic Analysis in URAT1 inhibitor 10 Model[1]

药代动力学分析[1]

Route Dose (mg/kg) t1/2 (h) tmax (h) Cmax (ng/mL) AUC(0-t) (ng·h/mL) AUC(0-∞) (ng·h/mL) MRT(0-∞) (h)
p.o. 50 1.9 0.25 8187 10050 10255 1.43

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hyperuricemia mice [1]
Dosage: 10 mg/kg； Once a day for seven days
Administration: p.o.
Result: Exhibited significant serum uric acid-lowering activity. The serum uric acid (SUA) levels decreased to 424 μM, achieving a reduction ratio of 53.9%. This performance was comparable to that of the positive control, Lesinurad (HY-15258), which also demonstrated significant SUA-lowering effects at the same dose.
Molecular Weight

427.44

Formula

C19H20F3N3O3S
CAS No.
SMILES

O=C(N1[C@@H](CCC1)CNS(C(F)(F)F)(=O)=O)C2=CC=NC3=C2C=C(C4CC4)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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URAT1 inhibitor 10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

URAT1 inhibitor 103012586-38-5URAT1Urate transporter 1SLC22A12Quinoline formamides， Hyperuricemia， Anti-inflammatory activity， Druggability， hyperuricemia miceInhibitorinhibitorinhibit

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