Search Result

Results for "

chromatin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (3) Antibiotic (1) Apoptosis (11) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (4) Caspase (3) CRISPR/Cas9 (1) CRM1 (2) DNA/RNA Synthesis (4) Drug Metabolite (1) Epigenetic Reader Domain (16) Estrogen Receptor/ERR (1) Ferroptosis (2) Fluorescent Dye (2) Fungal (1) GABA Receptor (1) HDAC (7) Histone Acetyltransferase (4) Histone Demethylase (1) Histone Methyltransferase (12) HIV (2) Influenza Virus (2) Keap1-Nrf2 (2) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitophagy (2) NF-κB (2) NO Synthase (1) Notch (1) Parasite (1) PARP (1) PD-1/PD-L1 (1) PROTACs (4) Reactive Oxygen Species (1) YAP (1)
By Research Areas:	Cancer (57) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (4)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123621

GNE-375	Epigenetic Reader Domain	Cancer
GNE-375 is a potent and highly selective BRD9 inhibitor with an IC₅₀ of 5 nM. GNE-375 shows >100-fold selective for BRD9 over BRD4, TAF1, and CECR2. GNE-375 decreases BRD9 binding to chromatin .

HY-141591

CYT296	Others	Others
CYT296 is a target *chromatin* de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research .

HY-D0944

Giemsa stain	Fluorescent Dye	Others
Giemsa stain can stain chromatin and nuclear membrane. Giemsa stain histopathologic detection of malaria and other microorganisms, such as Histoplasma, LeishmaniaToxoplasma, and Pneumocystis .Giemsa stain can used be in histology and microbiology .

HY-Y0649D

Lithium chloride, for molecular biology, 99%	Biochemical Assay Reagents	Others
Lithium chloride, for molecular biology, 99% can be used in the preparation of wash buffers for chromatin immunoprecipitation. Lithium chloride, for molecular biology, 99% is a kind of biological materials or organic compounds that are widely used in life science research .

HY-121862

CM03	DNA/RNA Synthesis	Cancer
CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells .

HY-114207

VinSpinIn	Epigenetic Reader Domain	Others
VinSpinIn is a Spindlin1 inhibitor (K_D: 9.9 nM for SPIN1_49-262). VinSpinIn is a chemical probe for tudor domain of Spindlin1. VinSpinIn can be used to study chromatin function .

HY-E70380

Endopeptidase, arctic marine microbial ArcticZymes Proteinase	Biochemical Assay Reagents	Others
Endopeptidase, arctic marine microbial (ArcticZymes Proteinase), a proteinase, is used for the digestion of chromatin, thus releasing naked DNA. As it is thermolable, it can be inactivated at temperatures compatible with RNA integrity and DNA as double strands .

HY-136572

CEM114	Epigenetic Reader Domain CRISPR/Cas9	Cancer
CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems .

HY-121315

BRD4097	HDAC	Metabolic Disease
BRD4097 is an inhibitor of histone deacetylase (HDAC). BRD4097 acts by inhibiting the activity of HDACs, especially HDAC 1,2 and 3, through metal chelation and spatial rejection mechanisms, and this inhibition may help regulate gene expression and alter chromatin structure, thereby affecting a variety of biological processes. BRD4097 is used to study the role of HDAC in cholesterol metabolism and NPC1 diseases .

HY-125209A

TH5427 hydrochloride	DNA/RNA Synthesis	Cancer
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC₅₀=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells .

HY-N6588

3,4,5-Tricaffeoylquinic acid 3,4,5-triCQA	Akt NF-κB	Inflammation/Immunology
3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) inhibits tumor necrosis factor-α-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-κB-pathways. 3,4,5-Tricaffeoylquinic acid induces cell cycle arrest at G0/G1, actin cytoskeleton organization, chromatin remodeling, neuronal differentiation, and bone morphogenetic protein signaling in human neural stem cells. 3,4,5-Tricaffeoylquinic acid has the potential for the research of aging-associated diseases .

HY-144874

AZ3391	PARP	Neurological Disease Cancer
AZ3391 is a potent inhibitor of PARP. AZ3391 is a quinoxaline derivative. PARP family of enzymes play an important role in a number of cellular processes, such as replication, recombination, chromatin remodeling, and DNA damage repair. AZ3391 has the potential for the research of diseases and conditions occurring in tissues in the central nervous system, such as the brain and spinal cord (extracted from patent WO2021260092A1, compound 23) .

HY-D1771

Thionin perchlorate	Fluorescent Dye	Others
Thionin perchlorate is a general nuclear stain for chromatin and mucin.

HY-W123005

Dimethyl pimelimidate dihydrochloride	Biochemical Assay Reagents	Others
Dimethyl pimelimidate dihydrochloride (DMP) is a protein crosslinker that can be used in chromatin immunoprecipitation experiments (ChIP) to enhance signal .

HY-111753

WDR5-IN-4	Histone Methyltransferase	Cancer
WDR5-IN-4 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a K_d of 0.1 nM. WDR5-IN-4 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity .

HY-111753A

WDR5-IN-4 TFA 3 Publications Verification	Histone Methyltransferase	Cancer
WDR5-IN-4 TFA is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a K_d of 0.1 nM. WDR5-IN-4 TFA displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity .

HY-153361

YD23	PROTACs	Cancer
YD23 is a SMARCA2 PROTAC. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. Moreover, YD23 decreases chromatin accessibility at enhancers of a number of genes including cell cycle and cell growth regulatory genes. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells mechanistically .

HY-161888

DCSM06	Epigenetic Reader Domain	Cancer
DCSM06 is an inhibitor for the bromodomain of SWI/SNF chromatin remodeling complexe SMARCA2 with an IC₅₀ of 9.7 μM

HY-100744

AS8351 NSC51355	Histone Demethylase	Cardiovascular Disease
AS8351 (NSC51355) is a KDM5B inhibitor, which can induce and sustain active chromatin marks to facilitate the induction of cardiomyocyte-like cells .

HY-161391

CW0134	CRM1	Cancer
CW0134 (Compound 12) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells .

HY-161392

CW2158	CRM1	Cancer
CW2158 (Compound 13) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells .

HY-162739

SMARCA2-IN-1	Epigenetic Reader Domain	Cancer
SMARCA2-IN-1 (Compound I-19) is an inhibitor for SWI/SNF chromatin remodeling complexe SMARCA2 with IC₅₀ >1000 nM in H1299 .

HY-12315

N-Oxalylglycine N-Oxaloglycine	Others	Cancer
N-Oxalylglycine (N-Oxaloglycine) is a broad-spectrum 2-oxoglutarate oxygenase inhibitor. N-Oxalylglycine can be used in studies on the hypoxic response and chromatin modifications in animals .

HY-121199

Germanicol	Apoptosis	Cancer
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-117846

MLAF50	DNA/RNA Synthesis	Cancer
MLAF50 is apotent REV1 UBM2-Ubiquitin interaction inhibitor. MLAF50 inhibits chromatin co-localization of REV1 with PCNA following DNA-damage induction .

HY-78695

JQ-1 (carboxylic acid) 5+ Cited Publications	Epigenetic Reader Domain PD-1/PD-L1	Cancer
JQ-1 carboxylic acid, a (+)-JQ-1 (HY-13030) derivative, is a potent BET bromodomain inhibitor. JQ-1 carboxylic acid can be used to synthesize PROTAC, which can target the degradation of BRD4.

HY-19553

LP99	Epigenetic Reader Domain	Inflammation/Immunology
LP99, an epigenetic probe, is a potent and selective inhibitor of the BRD7 and BRD9 bromodomains with a K_d of 99 nM against BRD9. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells .

HY-W250163

NAD+ lithium β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium	Biochemical Assay Reagents	Metabolic Disease
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .

HY-122645

SMARCA2-IN-4	Epigenetic Reader Domain	Cancer
SMARCA2-IN-4 (Compound 26) is an inhibitor for SWI/SNF chromatin remodeling complexe SMARCA by targeting the bromodomains. SMARCA2-IN-4 exhibits high affinity for PB1(5), SMARCA2B and SMARCA4 with K_d of 124, 262 and 417 nM .

HY-100431

IMR-1 5 Publications Verification	Notch	Cancer
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC₅₀ of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth .

HY-134355

ADPRP	Others	Others
ADPRP is an intranuclear enzyme whose main activity is to use NAD+ (nicotinamide adenine dinucleotide) as a substrate to add ADP-ribose units to chromatin-bound proteins, including the ADPRP enzyme itself. This process, called poly(ADP-ribosylation), is a post-translational modification that regulates the interaction between DNA and nuclear proteins .

HY-125276

TH5487 5+ Cited Publications	Others	Inflammation/Immunology
TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC₅₀ of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes .

HY-126428

ZL0580	HIV Epigenetic Reader Domain	Infection Inflammation/Immunology
ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter .

HY-18935

CBL0137 5+ Cited Publications Curaxin 137; CBL-C137	Histone Acetyltransferase MDM-2/p53 NF-κB	Cancer
CBL0137, a curaxin compound, is a histone chaperone facilitates chromatin transcription (FACT) inhibitor. CBL0137 downregulates NF-?B and activates p53. CBL0137 restores both histone H3 acetylation and trimethylation. CBL0137 is an anticancer agent. CBL0137 induces cancer cell apoptosis .

HY-W040129

Chromomycin A3 1 Publications Verification	Bacterial Fungal Apoptosis Antibiotic	Infection Cancer
Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 forms dimeric complexes with divalent cations, such as Mg ²⁺, which strongly binds to the GC rich sequence of DNA to inhibit DNA replication and transcription. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor .

HY-116501

VPC-14449	Androgen Receptor	Cancer
VPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD), with IC₅₀ of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer .

HY-15647

BRD9539 1 Publications Verification	Histone Methyltransferase	Cancer
BRD9539 is a histone methyltransferase G9a inhibitor with an IC₅₀ of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1 .

HY-155815

MS9715	Histone Methyltransferase PROTACs	Cancer
MS9715 is a potent and seletive NSD3-targeting PROTAC. MS9715 is designed by BI-9321, which binds NSD3’s PWWP1 domain, with an E3 ligase VHL ligand. MS9715 has the potental for NSD3-dependent cancer treatment research .

HY-157251A

UNC8153	Histone Methyltransferase	Cancer
UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a K_d of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2 .

HY-12455

Duocarmycin A	ADC Cytotoxin Apoptosis Caspase	Cancer
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels .

HY-125209

TH5427	Others	Cancer
TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells .

HY-161409

SC912	Androgen Receptor Apoptosis	Cancer
SC912 is an AR-V7 inhibitor (IC₅₀ = 0.36 μM). SC912 possesses safety, potency and selectivity. SC912 binds directly to AR-FL and AR-V7 proteins, inhibites nuclear localization and chromatin binding capabilities. SC912 exerts anticancer activity through inhibition of proliferation, induction of cell cycle arrest and apoptosis .

HY-157251

UNC8153 TFA	Histone Methyltransferase	Cancer
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a K_d of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2 .

HY-12926

ST7612AA1	HIV HDAC DNA/RNA Synthesis	Infection
ST7612AA1 is a histone deacetylase (HDAC) inhibitor that controls chromatin condensation and DNA transcription by removing acetyl groups from histones. ST7612AA1 is also a potent HIV reactivation inducer, and its reactivation activity is exerted without activating or proliferating CD4+T cells, and can be used in the study of HIV reactivation strategies and elimination of viral reservoirs .

HY-13808

UNC 0631 3 Publications Verification	Histone Methyltransferase	Cancer
UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC₅₀ of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC₅₀ of 25 nM .

HY-133121

WDR5-IN-1	Histone Methyltransferase Apoptosis	Cancer
WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a K_d of <0.02 nM. WDR5-IN-1 inhibits MLL1 histone methyltransferase (HMT) activity with an IC₅₀ of 2.2 nM. WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt’s lymphoma) lines .

HY-145688

HDAC-IN-33	HDAC	Cancer
HDAC-IN-33 is a potent HDAC inhibitor with IC₅₀s of 24, 46, and 47 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-33 possesses potent antiproliferation activities against tumor cells. HDAC-IN-33 shows potent antitumor efficacy in vivo That trigger antitumor immunity .

HY-145687

HDAC-IN-32	HDAC	Cancer
HDAC-IN-32 is a potent HDAC inhibitor with IC₅₀s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity .

HY-N0005

Curcumin Maximum Cited Publications 71 Publications Verification Diferuloylmethane; Natural Yellow 3; Turmeric yellow	Histone Acetyltransferase Epigenetic Reader Domain Keap1-Nrf2 Autophagy Mitophagy Influenza Virus Ferroptosis	Cancer
Curcumin (Diferuloylmethane), a natural phenolic compound, is a p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription. Curcumin shows inhibitory effects on NF-κB and MAPKs, and has diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification.

HY-10432G

A 83-01	Anaplastic lymphoma kinase (ALK)	Cancer
A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent ALK4/5/7 inhibitor .

Cat. No.	Product Name

HY-L024

Histone Modification Research Compound Library

670 compounds

A histone modification, a covalent post-translational modification (PTM) to histone proteins, includes methylation, phosphorylation, acetylation, ubiquitylation, and sumoylation, etc. In general, histone modifications are catalyzed by specific enzymes that act predominantly at the histone N-terminal tails involving amino acids such as lysine or arginine, as well as serine, threonine, tyrosine, etc. The PTMs made to histones can impact gene expression by altering chromatin structure or recruiting histone modifiers. Histone modifications act in diverse biological processes such as transcriptional activation/inactivation, chromosome packaging, and DNA damage/repair. Deregulation of histone modification contributes to many diseases, including cancer and autoimmune diseases.

MCE owns a unique collection of 670 bioactive compounds targeting Epigenetic Reader Domain, HDAC, Histone Acetyltransferase, Histone Demethylase, Histone Methyltransferase, Sirtuin, etc. Histone Modification Research Compound Library is a useful tool for histone modification research and drug screening.

HY-L040

Anti-diabetic Compound Library

793 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 793 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type

HY-D0944

Giemsa stain	Dyes
Giemsa stain can stain chromatin and nuclear membrane. Giemsa stain histopathologic detection of malaria and other microorganisms, such as Histoplasma, LeishmaniaToxoplasma, and Pneumocystis .Giemsa stain can used be in histology and microbiology .

HY-10432G

A 83-01 (GMP)	Fluorescent Dye
A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent ALK4/5/7 inhibitor .

HY-D1771

Thionin perchlorate	Fluorescent Dyes/Probes
Thionin perchlorate is a general nuclear stain for chromatin and mucin.

Cat. No.	Product Name	Type

HY-Y0649D

Lithium chloride, for molecular biology, 99%	Buffer Reagents
Lithium chloride, for molecular biology, 99% can be used in the preparation of wash buffers for chromatin immunoprecipitation. Lithium chloride, for molecular biology, 99% is a kind of biological materials or organic compounds that are widely used in life science research .

HY-10432G

A 83-01 (GMP)	Biochemical Assay Reagents
A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent ALK4/5/7 inhibitor .

HY-W543137

PT-ttpy	Biochemical Assay Reagents
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

HY-W250163

NAD+ lithium β-DPN lithium; β-NAD lithium; β-Nicotinamide Adenine Dinucleotide lithium	Biochemical Assay Reagents
NAD+ lithium (β-DPN lithium) is a lithium salt of nicotinamide adenine dinucleotide. NAD+ is a coenzyme in the REDOX reaction. NAD+ can directly or indirectly affect several key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell function .

Cat. No.	Product Name	Target	Research Area

HY-P2258

Histone H3 (1-34)	Peptides	Others
Histone H3 (1-34) is a peptide derived from human histone isotype 3.1. Histones are the main protein components of eukaryotic chromatin. Histone variants and histone modifications modulate chromatin structure, ensuring the precise operation of cellular processes associated with genomic DNA .

HY-P2465A

Histone H3 (1-35) (TFA)	Peptides	Cancer
Histone H3 (1-35) TFA is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells .

HY-P2254

H3K27(Me3) (15-34)	Peptides	Cancer
H3K27(Me3) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) .

HY-P2465

Histone H3 (1-35)	Peptides	Cancer
Histone H3 (1-35) is a 35-residue peptide of histone H3. Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells .

HY-P2555

Histone H3 (23-34)	Peptides	Others
Histone H3 (23-34) is the histone H3 amino acid residues 23 to 34. Histone H3 (23-34) contains lysine residues at positions 23 and 27 that are subject to methylation and acetylation .

HY-P2252

H3K27(Me) (15-34)	Peptides	Cancer
H3K27(Me) (15-34), a histone peptide, is a repressive chromatin markderived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) .

HY-P2253

H3K27(Me2) (15-34)	Peptides	Cancer
H3K27(Me2) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) .

Cat. No.	Product Name

HY-K0203

Protein A Magnetic Beads 10+ Cited Publications
Protein A Magnetic Beads provide a fast and convenient method for Immunoprecipitation and Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0205

Protein L Magnetic Beads 5+ Cited Publications
Protein L Magnetic Beads provide a fast and convenient method for Immunuoprecipitaion, Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0204

Protein G Magnetic Beads 20+ Cited Publications
Protein G Magnetic Beads provide a fast and convenient method for Immunoprecipitation and Co-Immunoprecipitation and Chromatin Immunoprecipitation.

HY-K0202

Protein A/G Magnetic Beads Maximum Cited Publications 603 Publications Verification
MCE Protein A/G Magnetic Beads provide a fast and convenient method for Immunoprecipitation, Co-Immunoprecipitation and Chromatin Immunoprecipitation.

Species:	Human (9)
Tag:	His (4) Tag Free (4) Strep (4) GST (1)
Source:	Sf9 insect cells (1) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P703421

	SPT16 Protein, Arabidopsis thaliana FACT complex subunit SPT16; Facilitates chromatin transcription complex subunit SPT16; SPT16; Arabidopsis thaliana; Mouse-ear cress	Others	E. coli
	SPT16 Protein, Arabidopsis thaliana is the recombinant SPT16, expressed by E. coli , with tag Free labeled tag. ,

HY-P703354

	BCORL1 Protein, Human (His, Strep) BCL-6 corepressor-like protein 1; BCORL1; Homo sapiens; Human; BCoR-L1; chromatin regulator; Repressor	Human	E. coli
	BCORL1 Protein, Human (His, Strep) is the recombinant human-derived BCORL1, expressed by E. coli , with Strep, His labeled tag. The total length of BCORL1 Protein, Human (His, Strep) is 118 a.a.,

HY-P703588

	RB1 Protein, Human (Strep) Retinoblastoma-associated protein; p105-Rb; p110-RB1; pRb; Rb; pp110; RB1; Homo sapiens; Human; Rb; chromatin regulator; DNA-binding; Repressor	Human	E. coli
	RB1 Protein, Human (Strep) is the recombinant human-derived RB1, expressed by E. coli , with Strep labeled tag. ,

HY-P702052

	CHMP6 Protein, Human CHMP6; Charged multivesicular body protein 6; chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20	Human	E. coli
	The CHMP6 protein is a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) for endosomal cargo protein sorting. MVB is essential for the degradation of membrane proteins transported to lysosomes. CHMP6 Protein, Human is the recombinant human-derived CHMP6 protein, expressed by E. coli , with tag free. The total length of CHMP6 Protein, Human is 201 a.a., .

HY-P702053

	CHMP6 Protein, Human (His, Strep) CHMP6; Charged multivesicular body protein 6; chromatin-modifying protein 6; Vacuolar protein sorting-associated protein 20; Vps20; hVps20	Human	E. coli
	The CHMP6 protein is a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) for endosomal cargo protein sorting. MVB is essential for the degradation of membrane proteins transported to lysosomes. CHMP6 Protein, Human (His, Strep) is the recombinant human-derived CHMP6 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of CHMP6 Protein, Human (His, Strep) is 201 a.a., .

HY-P703274

	USP3 Protein, Human (Active, Sf9, GST) Ubiquitin carboxyl-terminal hydrolase 3; Deubiquitinating enzyme 3; Ubiquitin thioesterase 3; Ubiquitin-specific-processing protease 3; USP3; Homo sapiens; Human; chromatin regulator; Hydrolase; Protease; Thiol protease; 3.4.19.12	Human	Sf9 insect cells
	USP3 Protein, Human (Active, Sf9, GST) is the recombinant human-derived USP3, expressed by Sf9 insect cells , with GST labeled tag. ,

HY-P702050

	CHMP4B Protein, Human CHMP4B; Charged multivesicular body protein 4b; chromatin-modifying protein 4b; CHMP4b; SNF7 homolog associated with Alix 1; SNF7-2; hSnf7-2; Vacuolar protein sorting-associated protein 32-2; Vps32-2; hVps32-2	Human	E. coli
	CHMP4B protein may be a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) and sorting of endosomal cargo proteins. It is essential for the degradation of membrane proteins delivered to lysosomes. CHMP4B Protein, Human is the recombinant human-derived CHMP4B protein, expressed by E. coli , with tag free. The total length of CHMP4B Protein, Human is 224 a.a., .

HY-P702051

	CHMP4B Protein, Human (His, Strep) CHMP4B; Charged multivesicular body protein 4b; chromatin-modifying protein 4b; CHMP4b; SNF7 homolog associated with Alix 1; SNF7-2; hSnf7-2; Vacuolar protein sorting-associated protein 32-2; Vps32-2; hVps32-2	Human	E. coli
	CHMP4B protein may be a core component of ESCRT-III and plays a key role in the formation of multivesicular bodies (MVBs) and sorting of endosomal cargo proteins. It is essential for the degradation of membrane proteins delivered to lysosomes. CHMP4B Protein, Human (His, Strep) is the recombinant human-derived CHMP4B protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of CHMP4B Protein, Human (His, Strep) is 224 a.a., .

HY-P701528

	HLTF Protein, Human HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free. The total length of HLTF Protein, Human is 117 a.a., .

HY-P701529

	HLTF Protein, Human (His) HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag. The total length of HLTF Protein, Human (His) is 117 a.a., .

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HY-P81743

	p150 CAF1 Antibody (YA1488) CHAF1A; CAF; CAF1P150; chromatin assembly factor 1 subunit A; CAF-1 subunit A; chromatin assembly factor I p150 subunit; CAF-I 150 kDa subunit; CAF-I p150; hp150	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	p150 CAF1 Antibody (YA1488) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1488), targeting p150 CAF1, with a predicted molecular weight of 107 kDa (observed band size: 150 kDa). p150 CAF1 Antibody (YA1488) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human background.

HY-P83440

	Polycomb Protein SUZ12 Antibody (YA3185) SUZ12; CHET9; JJAZ1; KIAA0160; Polycomb protein SUZ12; chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog	WB, ICC/IF, IP	Human, Mouse, Rat
	Polycomb Protein SUZ12 Antibody (YA3185) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3185), targeting Polycomb Protein SUZ12, with a predicted molecular weight of 83 kDa (observed band size: 83 kDa). Polycomb Protein SUZ12 Antibody (YA3185) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.

HY-P83496

	SMARCA2 Antibody (YA3241) SMARCA2; BAF190B; BRM; SNF2A; SNF2L2; Probable global transcription activator SNF2L2; ATP-dependent helicase SMARCA2; BRG1-associated factor 190B; BAF190B; Protein brahma homolog; hBRM; SNF2-alpha; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2	WB, IHC-F, IHC-P, ICC/IF	Human
	SMARCA2 Antibody (YA3241) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3241), targeting SMARCA2, with a predicted molecular weight of 181 kDa (observed band size: 190 kDa). SMARCA2 Antibody (YA3241) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

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Cat. No.	Product Name		Classification

HY-159451

PROTAC SMARCA2 degrader-7		Azide
PROTAC SMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader for SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A (SMARCA) SMARCA2. PROTAC SMARCA2 degrader-7 degrades SMARCA2 and SMARCA4 in MV411 with DC₅₀ of <100 and 100-500 nM. (Pink: Ligand for target protein (HY-159542); Black: Linker (HY-159538); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))

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