VinSpinIn

Cat. No.: HY-114207: FAQs
Data Sheet Handling Instructions

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VinSpinIn is a Spindlin1 inhibitor (K_D: 9.9 nM for SPIN1_49-262). VinSpinIn is a chemical probe for tudor domain of Spindlin1. VinSpinIn can be used to study chromatin function.

For research use only. We do not sell to patients.

VinSpinIn Chemical Structure

CAS No. : 2380021-98-5

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Description

VinSpinIn is a Spindlin1 inhibitor (K_D: 9.9 nM for SPIN1_49-262). VinSpinIn is a chemical probe for tudor domain of Spindlin1. VinSpinIn can be used to study chromatin function^[1].

IC₅₀ & Target

KD: 9.9 nM for SPIN1_49-262^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
U2OS	EC₅₀	270 nM Compound: 35	Inhibition of C-terminal Halotag-histone 3.3 tagged SPIN1 (unknown origin) transfected in human U2OS cells cotransfected with nano-luciferase at 1 uM using NanoBRET Nano-Glo substrate as substrate incubated for 24 hrs by NanoBRET assay Inhibition of C-terminal Halotag-histone 3.3 tagged SPIN1 (unknown origin) transfected in human U2OS cells cotransfected with nano-luciferase at 1 uM using NanoBRET Nano-Glo substrate as substrate incubated for 24 hrs by NanoBRET assay	[PMID: 31550156]

Molecular Weight

738.96

Formula

C₄₂H₅₈N₈O₄

CAS No.

2380021-98-5

SMILES

CC1(C)C(N)=NC2=CC(OCCCN3CC(C=CC(OCCC4=CN(CC(N5CCC(CCN6CCCC6)CC5)=O)N=N4)=C7)=C7C3)=C(OCC8CC8)C=C21

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fagan V, et al. A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. J Med Chem. 2019 Oct 24;62(20):9008-9025. [Content Brief]

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VinSpinIn2380021-98-5Epigenetic Reader DomainchromatinSpindlin1tudor domainInhibitorinhibitorinhibit

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