2. Apoptosis
  3. Apoptosis
  4. Germanicol

Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage.

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Germanicol Chemical Structure

Germanicol Chemical Structure

CAS No. : 465-02-1

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Germanicol Related Antibodies

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Description

Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage[1].

In Vitro

Germanicol (0-100 µM; 6 h and 24 h) shows selective, potent and dose-dependent cytotoxicity in HCT-116 and HT29 human colon cancer cells. Germanicol induces HCT-116 and HT29 cells death in a dose-dependent manner[1].
Germanicol (0-100 µM; 48 h) induces HCT-116 colon cancer cells apoptosis in a dose-dependent manner[1].
Germanicol (0-100 µM; 0-48 h) inhibits HCT-116 colon cancer cells migration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Germanicol Related Antibodies

Cell Viability Assay[1]

Cell Line: Human colon cancer cell lines HCT-116 (colon), HT29 (colon) and Human colon fibroblast (CCD-18Co).
Concentration: 0, 5, 10, 20, 40 and 100 µM.
Incubation Time: 6 h and 24 h.
Result: Showed insignificant cytotoxicity below 20 μM and exhibited potent and dose-dependent cytotoxic effect on both HCT-116 and HT29 colon cancer cells at higher doses over 40 µM.

Apoptosis Analysis[1]

Cell Line: HCT-116 colon cancer cells.
Concentration: 0, 10, 40 and 100 µM.
Incubation Time: 48 h.
Result: Induced potent and dose-dependent chromatin condensation, accompanied by subsequent DNA damage.

Cell Migration Assay [1]

Cell Line: HCT-116 colon cancer cells.
Concentration: 0, 10, 40 and 100 µM.
Incubation Time: 0, 12, 24 and 48 h.
Result: Decreased cell migration tendency.
Molecular Weight

426.72

Formula

C30H50O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC[C@]4([H])C5=CC(C)(C)CC[C@@](C)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥99.0%

SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References
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Germanicol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Germanicol465-02-1ApoptosisHCT-116HT29CCD-18CoMigrationInhibitorinhibitorinhibit

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