2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. CM03

CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells.

For research use only. We do not sell to patients.

CM03 Chemical Structure

CM03 Chemical Structure

CAS No. : 2101208-44-8

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Based on 1 publication(s) in Google Scholar

CM03 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells[1][2].

IC50 & Target

DNA synthesis[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
24 nM
Compound: CM03
Growth inhibition of human A549 cells after 96 hrs by SRB assay
Growth inhibition of human A549 cells after 96 hrs by SRB assay
[PMID: 29356532]
BXPC-3 GI50
15.5 nM
Compound: CM03
Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
BXPC-3 IC50
19 nM
Compound: CM03
Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay
Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay
[PMID: 29356532]
CAPAN-1 IC50
16 nM
Compound: CM03
Growth inhibition of human Capan1 cells after 96 hrs by SRB assay
Growth inhibition of human Capan1 cells after 96 hrs by SRB assay
[PMID: 29356532]
CAPAN-1 GI50
26.5 nM
Compound: CM03
Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
MCF7 IC50
159 nM
Compound: CM03
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
[PMID: 29356532]
MIA PaCa-2 GI50
400 nM
Compound: CM03
Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 29356532]
MIA PaCa-2 IC50
7 nM
Compound: CM03
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
[PMID: 29356532]
MIA PaCa-2 GI50
9 nM
Compound: CM03
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
PANC-1 GI50
15.6 nM
Compound: CM03
Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
PANC-1 IC50
18 nM
Compound: CM03
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
[PMID: 29356532]
PANC-1 GI50
400 nM
Compound: CM03
Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 29356532]
WI-38 IC50
1190 nM
Compound: CM03
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
[PMID: 29356532]
In Vitro

CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA (HY-10221) in MIA PaCa-2 and PANC-1[1].
CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CM03 Related Antibodies

Western Blot Analysis[1]

Cell Line: MIA PaCa-2 and PANC-1
Concentration: 0.4 μM
Incubation Time: 24 h for MIA PaCa-2, 48 h for PANC-1
Result: Significantly increased the level of γ-H2AX protein when in combination with SAHA (HY-10221) (1 μM).

Cell Proliferation Assay[2]

Cell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3
Concentration: 0-100 nM
Incubation Time: 96 h
Result: Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI50s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.
Molecular Weight

632.75

Formula

C34H44N6O6
CAS No.
Appearance

Solid

Color

Brown to dark brown

SMILES

O=C(C1=CC=C2C3=O)N(C(C4=C1C2=C(C=C4NCCN5CCCC5)C(N3CCCN6CCOCC6)=O)=O)CCCN7CCOCC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2 mg/mL (3.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5804 mL 7.9020 mL 15.8040 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.73%

SDS (251 KB)

COA (250 KB) HNMR (295 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5804 mL 7.9020 mL 15.8040 mL 39.5101 mL
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CM03 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM032101208-44-8CM 03CM-03DNA/RNA SynthesisDSBsDNAchromatinpancreatic cancerInhibitorinhibitorinhibit

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