ST7612AA1

Cat. No.: HY-12926: FAQs
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ST7612AA1 is a histone deacetylase (HDAC) inhibitor that controls chromatin condensation and DNA transcription by removing acetyl groups from histones. ST7612AA1 is also a potent HIV reactivation inducer, and its reactivation activity is exerted without activating or proliferating CD4+T cells, and can be used in the study of HIV reactivation strategies and elimination of viral reservoirs.

For research use only. We do not sell to patients.

ST7612AA1 Chemical Structure

CAS No. : 1428535-92-5

Size	Price	Stock
1 mg	USD 320	Ask For Quote & Lead Time
5 mg	USD 800	Ask For Quote & Lead Time
10 mg	USD 1170	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

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•Related Small Molecules:

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HIV HIV-1 HIV-2

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	0.075 μM Compound: 117, ST7612	Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay Cytotoxicity against human HCT116 cells after 24 hrs by SRB assay	[PMID: 25233084]
NCI-H460	IC₅₀	0.005 μM Compound: 117, ST7612	Inhibition of HDAC-mediated histone H4 deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis Inhibition of HDAC-mediated histone H4 deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis	[PMID: 25233084]
NCI-H460	IC₅₀	0.07 μM Compound: 117, ST7612	Cytotoxicity against human NCI-H460 cells after 24 hrs by SRB assay Cytotoxicity against human NCI-H460 cells after 24 hrs by SRB assay	[PMID: 25233084]
NCI-H460	IC₅₀	0.2 μM Compound: 117, ST7612	Inhibition of HDAC-mediated tubulin deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis Inhibition of HDAC-mediated tubulin deacetylation in human NCI-H460 cells after 3 hrs by Western blot analysis	[PMID: 25233084]

Molecular Weight

405.51

Formula

C₂₀H₂₇N₃O₄S

CAS No.

1428535-92-5

SMILES

CC(SCCCCC[C@H](NC([C@@H](CC1)NC1=O)=O)C(NC2=CC=CC=C2)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Badia, et al. The thioacetate-ω (γ-lactam carboxamide) HDAC inhibitor ST7612AA1 as HIV-1 latency reactivation agent. Antiviral research 123 (2015): 62-69. [Content Brief]

ST7612AA1 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST7612AA11428535-92-5HIVHDACDNA/RNA SynthesisHuman immunodeficiency virusHistone deacetylasesReactivation inducerTranscriptional activityCD4+T cellsInhibitorinhibitorinhibit

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