2. Epigenetics Cell Cycle/DNA Damage
  3. Epigenetic Reader Domain CRISPR/Cas9
  4. CEM114

CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems.

For research use only. We do not sell to patients.

CEM114 Chemical Structure

CEM114 Chemical Structure

CAS No. : 2279062-54-1

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CEM114 Related Antibodies

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Description

CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

In Vitro

CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CEM114 Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK 293T cells
Concentration: 200 nM
Incubation Time: 48 hours
Result: Significantly activated the GFP signal.
Molecular Weight

1612.98

Formula

C84H122FN9O19S
CAS No.
SMILES

CC1=NOC(C)=C1C2=CC=C(C3=C2)N(C(CCC(C=C4)=CC(F)=C4OCC(N=N5)=CN5CCOCCOCCOCCNC(CCSCCC[C@H](/C=C(C[C@@H](C[C@@H]([C@](O[C@]6(C7=O)O)([H])[C@H](C[C@H]6C)OC)OC)C)\C)C(C[C@@H]([C@H]([C@H](OC([C@@](CCCC8)([H])N8C7=O)=O)/C(C)=C/[C@H](CC[C@H]9O)C[C@H]9OC)C)O)=O)=O)=N3)CCN%10CCOCC%10
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CEM114 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CEM1142279062-54-1CEM 114CEM-114Epigenetic Reader DomainCRISPR/Cas9chemicalepigeneticmodifiersrecruitendogenouschromatinmachineryCRISPR-Cas9systemInhibitorinhibitorinhibit

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HY-136572
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