2. Membrane Transporter/Ion Channel
  3. CRM1
  4. CW2158

CW2158 (Compound 13) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells.

For research use only. We do not sell to patients.

CW2158 Chemical Structure

CW2158 Chemical Structure

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CW2158 Related Antibodies

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Description

CW2158 (Compound 13) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1].

In Vitro

CW2158 (10 nM-10 μM) inhibits the expression of IL-2 (6 h) and viability (24 h) of Jurkat cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CW2158 Related Antibodies

Cell Viability Assay[1]

Cell Line: Jurkat
Concentration: 10 nM-10 μM
Incubation Time: 24 h
Result: Inhibited cell viability of Jurkats.
Molecular Weight

340.23

Formula

C14H8F4N4O2
SMILES

FC(F)(F)C(N=C1NN2C(C=C(C)C2=O)=O)=NC3=C1C(F)=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CW2158 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CW2158CW 2158CW-2158CRM1Chromosomal Maintenance 1Exportin 1XPO1JurkatSIATselectiveInhibitorinhibitorinhibit

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