TH5427 hydrochloride

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TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC₅₀=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.

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TH5427 hydrochloride Chemical Structure

CAS No. : 2253744-57-7

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Description	TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC₅₀=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells^[1].
In Vitro	TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47D^WT cells^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. TH5427 hydrochloride Related Antibodies
Molecular Weight	527.79
Formula	C₂₀H₂₁Cl₃N₈O₃
CAS No.	2253744-57-7
SMILES	[H]Cl.O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250. Published 2018 Jan 17. [Content Brief]