2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. TH5427 hydrochloride

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.

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TH5427 hydrochloride Chemical Structure

TH5427 hydrochloride Chemical Structure

CAS No. : 2253744-57-7

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TH5427 hydrochloride Related Antibodies

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Description

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1].

In Vitro

TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47DWT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TH5427 hydrochloride Related Antibodies
Molecular Weight

527.79

Formula

C20H21Cl3N8O3
CAS No.
SMILES

[H]Cl.O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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TH5427 hydrochloride Related Classifications

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Keywords:

TH54272253744-57-7TH 5427TH-5427DNA/RNA SynthesisNUDT5MTH1ATPsynthesischromatinremodelinggeneregulationproliferationbreastcancercellsInhibitorinhibitorinhibit

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TH5427 hydrochloride
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