A 83-01 

A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent ALK4/5/7 inhibitor^[1][2].

A 83-01 (GMP) induces human foreskin fibroblasts converts into ardiomyocyte-like cells a more open-chromatin conformation at key heart developmental genes^[1].
A 83-01 (GMP) induces cord blood or fetal liver-derived CD34⁺ cells converts into pluripotent cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A 83-01 (GMP) (human foreskin fibroblast with aMHC-GFP; incubates in vitro 6 days than transplanted into the infarcted hearts of immunodeficient mice) induces fibroblasts converts into cardiomyocyte-like cells in infarcted mouse heart^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

421.52

C₂₅H₁₉N₅S

909910-43-6

Solid

White to off-white

S=C(N1N=C(C2=NC(C)=CC=C2)C(C3=CC=NC4=CC=CC=C34)=C1)NC5=CC=CC=C5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Guan J, et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022 May;605(7909):325-331.  [Content Brief]

  [2]. Liu J, et al. Efficient episomal reprogramming of blood mononuclear cells and differentiation to hepatocytes with functional drug metabolism. Exp Cell Res. 2015 Nov 1;338(2):203-13.  [Content Brief]