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Results for "

juvenile

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (2) Cannabinoid Receptor (1) CRFR (1) Cytochrome P450 (1) Dopamine Receptor (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Fungal (1) Insecticide (5) Isotope-Labeled Compounds (2) mGluR (1) NO Synthase (2) Parasite (3) Phosphatase (1) Potassium Channel (1) Progesterone Receptor (1) Proton Pump (1) Ras (1) SARS-CoV (1) TNF Receptor (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Endocrinology (6) Infection (6) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (5)

By Targets:

Apoptosis (1)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (2)

Cannabinoid Receptor (1)

CRFR (1)

Cytochrome P450 (1)

Dopamine Receptor (1)

Endogenous Metabolite (1)

Estrogen Receptor/ERR (1)

Farnesyl Transferase (1)

Fungal (1)

Insecticide (5)

Isotope-Labeled Compounds (2)

mGluR (1)

NO Synthase (2)

Parasite (3)

Phosphatase (1)

Potassium Channel (1)

Progesterone Receptor (1)

Proton Pump (1)

Ras (1)

SARS-CoV (1)

TNF Receptor (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (2)

Endocrinology (6)

Infection (6)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7240

*(Rac)-Juvenile* hormone III**	Others	Endocrinology
(Rac)-Juvenile hormone III, a natural compound that can be isolated from farnesoic acid ,is the most widely distributed Juvenile hormone homologue .

HY-N7240S

*(Rac)-Juvenile* Hormone III-d3**	Isotope-Labeled Compounds	Others
Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III[1].

HY-B1161

Methoprene Maximum Cited Publications 12 Publications Verification ZR-515	Insecticide	Others
Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-122062

Fenoxycarb	Insecticide	Others
Fenoxycarb, a juvenile hormone, is an insecticide and can be used for agricultural pest control .

HY-B1161R

Methoprene (Standard)	Insecticide	Others
Methoprene (Standard) is the analytical standard of Methoprene. This product is intended for research and analytical applications. Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-P5866

Allatotropin Manse-AT	Endogenous Metabolite	Endocrinology
Allatotropin (Manse-AT) is a 13 amino acid neuropeptide. Allatotropin activates inositol 1,4,5-trisphosphate (IP3) pathway, and the biosynthesis of juvenile hormone (JH) in Manduca sexta .

HY-122530

Juvocimene I	Insecticide	Endocrinology
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .

HY-123897

Chamaejasmenin C	Parasite	Infection
Chamaejasmenin C, a biflavanone, shows nematicidal activity against second-stage juveniles (J2s) of B. xylophilus and B. mucronatus .

HY-B1161S

Methoprene-d7 ZR-515-d₇	Isotope-Labeled Compounds	Others
Methoprene-d₇ is the deuterium labeled Methoprene[1]. Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[2][3].

HY-P1786

Allatostatin II	Potassium Channel	Neurological Disease
Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-B2031

Pyriproxyfen S-31183	Autophagy Parasite	Infection
Pyriproxyfen is a juvenile hormone analog, preventing larvae from developing into adulthood and thus rendering them unable to reproduce.

HY-121973

Juvocimene II	Others	Endocrinology
Juvocimene II is a compound with extremely high juvenile hormone (JH) activity, exhibiting potent insect hormone mimetic capabilities .

HY-P0001

Thymus factor X TFX-Jelfa	Biochemical Assay Reagents	Inflammation/Immunology
Thymic factor X (TFX-Jelfa) is an aqueous extract from juvenile calf thymuses and a natural stimulator of lymphocyte function .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR	Endocrinology
Tetracosactide acetate is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P4989

Type A Allatostatin III	Biochemical Assay Reagents	Infection
Type A Allatostatin III (allatostatin 3) is a blood-brain barrier permeable and reversible neuropeptide that inhibits hormone synthesis in juvenile female cockroaches. Type A Allatostatin III can be used in pesticide research .

HY-P99207

Lenzilumab KB 003	SARS-CoV	Cancer
Lenzilumab (KB 003) is a human monoclonal antibody targeting CSF2/GM-CSF for COVID-19, chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) studies .

HY-N3340

Macrocarpal I	Fungal	Infection
Macrocarpal I is a phloroglucinol coupled sesquiterpenoid with antifungal activity. Macrocarpal I against C. glabrata with an IC₅₀ value of 0.75 μg/mL. Macrocarpal I can be isolated from the juvenile leaves of E. maideni .

HY-100371

(RS)-MCPG 1 Publications Verification alpha-MCPG	mGluR	Neurological Disease
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons .

HY-105294

FR 64822	Dopamine Receptor	Others
FR 64822 is a dopamine D2 receptor agonist that can induce antinociceptive activity in rats and mice by indirectly stimulating dopamine D2 receptors. FR 64822 can promote penile erection in juvenile rats and improve amnesia in rats induced by scopolamine during passive avoidance tasks .

HY-P10390

Insecticidal agent 11	Parasite	Infection
Insecticidal agent 11 (compound Q6) is a potent insect growth regulator (IGR)-based insecticide. Insecticidal agent 11 shows high insecticidal activity against Diploptera punctata by inhibiting juvenile hormone (JH) biosynthesis. Insecticidal agent 11 also exhibits insecticidal activity against Plutella xylostella .

HY-108847

Etanercept 5+ Cited Publications	TNF Receptor Bacterial	Inflammation/Immunology Cancer
Etanercept, a dimeric fusion protein that binds TNF, acts as a TNF inhibitor. Etanercept competitively inhibits the binding of both TNF-α and TNF-β to cell surface TNF receptors, rendering TNF biologically inactive. Etanercept shows efficacy against rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis .

HY-W014566

4-Nitro-3-(trifluoromethyl)phenol 3-(Trifluoromethyl)-4-Nitrophenol; TFM	Insecticide Cytochrome P450	Infection
4-Nitro-3-(trifluoromethyl)phenol (TFM) is a piscicide that is toxic to lampreys (P. marinus) (LC₅₀ values ??are 1.97-2.11 for cysts, 2.05-2.21 for fry, 1.6-2.45 for juveniles, and 1.6-1.63 for adults, respectively). 4-Nitro-3-(trifluoromethyl)phenol is also toxic to juvenile lake sturgeons (A. fulvescens) less than 100 mm, but is nontoxic to a variety of other fish species. 4-Nitro-3-(trifluoromethyl)phenol (50 μM) dissociates oxidative phosphorylation by 22% and 28% in isolated livers of lampreys and rainbow trout (O. mykiss), respectively. 4-Nitro-3-(trifluoromethyl)phenol can be used to control lamprey larval populations.

HY-B1161A

S-Methoprene 2 Publications Verification (+)-Methoprene; (7S)-Methoprene	Cannabinoid Receptor	Others
S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [ ³H]CP-55940 to the CB1 receptor (IC₅₀: 19.31 μM) .

HY-69019

7-Nitroindazole 1 Publications Verification	NO Synthase	Cardiovascular Disease Neurological Disease
7-Nitroindazole is a selective and BBB-penatrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole can inhibit the activity of central NOS with an IC₅₀ of 0.47 μM in the cerebellum of mice. 7-Nitroindazole has anti-injurious and neuroprotective properties .

HY-69019A

7-Nitroindazole sodium	NO Synthase	Cardiovascular Disease Neurological Disease
7-Nitroindazole sodium is a selective and BBB-penatrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC₅₀ of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties .

HY-108786

Asfotase alfa ENB-0040	Phosphatase	Metabolic Disease
Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 ^?/? knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .

HY-159959

cis-3-Indoleacrylic acid	Proton Pump	Others
cis-3-Indoleacrylic acid is a nematicidal compound that can be isolated from Streptomyces youssoufiensis YMF3.862. cis-3-Indoleacrylic acid is also a V‑ATPase inhibitor, and inhibits V-ATPase expression and enzyme activity. cis-3-Indoleacrylic acid causes Meloidogyne incognita juveniles to have swollen bodies with apparent cracks on the cuticle surface (LC₅₀: 16.31 μg/mL). cis-3-Indoleacrylic acid inhibits H ⁺ accumulation in nematode bodies .

HY-16290

Lonaprisan ZK 230211; BAY86 5044	Progesterone Receptor	Endocrinology
Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC₅₀ of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect .

HY-120044

L-739749	Farnesyl Transferase Ras	Cancer
L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro .

HY-121149B

(E/Z)-Droloxifene (E/Z)-3-Hydroxytamoxifen	Estrogen Receptor/ERR Apoptosis	Cancer
(E/Z)-Droloxifene is a mixture of (E)-droloxifene (a selective estrogen receptor modulator) and (Z)-droloxifene. (E)-Droloxifene binds to the estrogen receptor (ER) with an IC₅₀ value of 24 nM in rabbit uterine homogenates. (E)-Droloxifene increases uterine weight in immature rats, and reduces estradiol-induced increases in uterine weight in juvenile rats. (E)-Droloxifene also inhibits 17β-estradiol-stimulated growth of MCF-7, ZR-75-1, and T47D human breast cancer cells. (Z)-Droloxifene binds weakly to ER and has no estrogenic or antiestrogenic activity .

Cat. No.	Product Name

HY-L040

Anti-diabetic Compound Library	829 compounds
Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage. The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes. MCE Anti-diabetic Compound Library owns a unique collection of 829 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Anti-diabetic Compound Library

829 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 829 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Type