2. Metabolic Enzyme/Protease MAPK/ERK Pathway GPCR/G Protein
  3. Farnesyl Transferase Ras
  4. L-739749

L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro.

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L-739749 Chemical Structure

L-739749 Chemical Structure

CAS No. : 156511-34-1

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L-739749 Related Antibodies

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Description

L-739749 is a farnesyl transferase inhibitor. L-739749 inhibits the selective hypersensitivity of JMML cells to granulocyte-macrophage colony-stimulating factor (GM-CSF) by blocking the prenylation of Ras. L-739749 exhibits a strong inhibitory effect on the growth of primary human JMML cells in vitro[1].

Molecular Weight

531.73

Formula

C24H41N3O6S2
CAS No.
SMILES

O=C(OC)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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L-739749 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-739749156511-34-1L739749L 739749Farnesyl TransferaseRasFtaseinhibitorjuvenile myeloid leukemiaGM-CSFgrowth inhibitionJMML primary cellsInhibitorinhibit

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