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Asfotase alfa  (Synonyms: ENB-0040)

Cat. No.: HY-108786
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Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2?/? knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP).

For research use only. We do not sell to patients.

CAS No. : 1174277-80-5

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Description

Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2?/? knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP)[1].

Species

Human
In Vivo

Asfotase alfa (0.5-8.2 mg/kg; s.c. once daily for 43 days) shows dose-response relationships that strongly support the pharmacological efficacy for HPP[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Akp2−/− knockout mice[1]
Dosage: 0.5, 2.0 and 8.2 mg/kg
Administration: Subcutaneous injection; once daily for 43 days
Result: Dose-dependently increased the survival rate of mice, bone mineralization and prevention of mineralization defects of the feet, rib cage, lower limbs, jaw bones, the median survival, body weight, and bone length. Showed a clear relationship between daily dose and achieving a healthy BW and the ED80 (the dose that prevents bone defects in 80% of mice) was 3.2, 2.8 and 2.9 mg/kg/day for these sites. Remained increasing urinary PPi concentrations in all treatment groups.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Asfotase alfa]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [ALPL (alkaline phosphatase, TNSALP, tissue non-specific alkaline phosphatase)18-502]2-IGHG1 Fc (Fragment constant)-Asp-Ile-deca-aspartate
Biological Activity
  • Immobilized Asfotase alfa can bind Anti-Alkaline Phosphatase/ALPL Antibody. The EC50 for this effect is 3.417 ng/mL.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asfotase alfa1174277-80-5ENB-0040ENB0040ENB 0040Othersenzyme replacement therapyERTbone-targetedHPPhypophosphatasiaInhibitorinhibitorinhibit

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