2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. S-Methoprene

S-Methoprene  (Synonyms: (+)-Methoprene; (7S)-Methoprene)

Cat. No.: HY-B1161A Purity: 96.03%
COA Handling Instructions

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S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [3H]CP-55940 to the CB1 receptor (IC50: 19.31 μM).

For research use only. We do not sell to patients.

S-Methoprene Chemical Structure

S-Methoprene Chemical Structure

CAS No. : 65733-16-6

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Based on 1 publication(s) in Google Scholar

Other Forms of S-Methoprene:

S-Methoprene Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE S-Methoprene

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CB1 CB2

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  • Purity & Documentation

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Description

S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [3H]CP-55940 to the CB1 receptor (IC50: 19.31 μM)[1][2].

IC50 & Target

CB1 receptor[2]
In Vitro

PMSF (HY-B0496) inhibits [3H]CP-55940 binding to mouse meninges. S-Methoprene (4 μM) inhibits [3H]CP-55940 binding by 27.32± 4.11% and 28.16± 4.17% in the absence and presence of 50 μM PMSF, respectively[2].
S-Methoprene also inhibits CP-55940-stimulated binding of [35S]GTPγS to mouse meninges. S-Methoprene inhibits CB1 receptor binding in a concentration-dependent manner with Ki of 2.13 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

S-Methoprene Related Antibodies
Molecular Weight

310.47

Formula

C19H34O3
CAS No.
Appearance

Liquid (Density: 0.913 g/ml)

Color

Colorless to light yellow

SMILES

CC(C)(OC)CCC[C@H](C)C/C=C/C(C)=C/C(OC(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (322.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2209 mL 16.1046 mL 32.2092 mL
5 mM 0.6442 mL 3.2209 mL 6.4418 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.05 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (8.05 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 96.03%

COA (241 KB) HNMR (210 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2209 mL 16.1046 mL 32.2092 mL 80.5231 mL
5 mM 0.6442 mL 3.2209 mL 6.4418 mL 16.1046 mL
10 mM 0.3221 mL 1.6105 mL 3.2209 mL 8.0523 mL
15 mM 0.2147 mL 1.0736 mL 2.1473 mL 5.3682 mL
20 mM 0.1610 mL 0.8052 mL 1.6105 mL 4.0262 mL
25 mM 0.1288 mL 0.6442 mL 1.2884 mL 3.2209 mL
30 mM 0.1074 mL 0.5368 mL 1.0736 mL 2.6841 mL
40 mM 0.0805 mL 0.4026 mL 0.8052 mL 2.0131 mL
50 mM 0.0644 mL 0.3221 mL 0.6442 mL 1.6105 mL
60 mM 0.0537 mL 0.2684 mL 0.5368 mL 1.3421 mL
80 mM 0.0403 mL 0.2013 mL 0.4026 mL 1.0065 mL
100 mM 0.0322 mL 0.1610 mL 0.3221 mL 0.8052 mL
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S-Methoprene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Methoprene65733-16-6(+)-Methoprene (7S)-MethopreneCannabinoid ReceptorCB1 receptorSanguinarineChelerythrinePiperonyl butoxideMethopreneMouse brainInhibitorinhibitorinhibit

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