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Isoforms Recommended: Adenosine A1 receptor (A1R)
Results for "

rA1

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

4

Peptides

10

Inhibitory Antibodies

6

Natural
Products

15

Recombinant Proteins

2

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2506

    Others Cardiovascular Disease
    Ginsenoside Ra1 is a component from ginseng, inhibits protein tyrosine kinase (PTK) activation induced by hypoxia/reoxygenation [1].
    Ginsenoside Ra1
  • HY-103174

    Adenosine Receptor Cardiovascular Disease
    MRS1334 is a potent and selective human adenosine A3 receptor antagonist with Kis of 2.69 nM, >100 nM, >100 nM for hA3, rA1, rA2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment [1] . MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MRS1334
  • HY-139314

    Adenosine Receptor Metabolic Disease
    A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively [1].
    A2B receptor antagonist 2
  • HY-103175

    Adenosine Receptor Neurological Disease
    PSB36 is a potent and selective antagonist of adenosine A1 receptor, with Kis 0.12 nM, 187 nM, 552 nM, 2300 nM, and 6500 nM for rA1, hA2B, rA2A, hA3 and rA3 receptors respectively. PSB36 can be used for the research of hyperalgesia [1] .
    PSB36
  • HY-P990016

    ARGX-112

    Interleukin Related Inflammation/Immunology
    Temtokibart is a humanized IgG1λ2 antibody targeting IL22RA1. Expressed by cells lacking the glutamine synthetase gene.
    Temtokibart
  • HY-103177

    Adenosine Receptor Inflammation/Immunology
    PSB-10 hydrochloride is a potent and selective antagonist of human adenosine A3 receptor (A3AR), with a Ki of 0.44 nM. PSB-10 hydrochloride shows more than 800-fold selectivity for hA3 over rA1, rA2A, hA1, hA2A and hA2B receptors (Ki=805, 6040, 1700, 2700, 30000 nM, respectively). PSB-10 hydrochloride produces thermal hyperalgesia in mice [1] .
    PSB-10 hydrochloride
  • HY-RS06688

    Small Interfering RNA (siRNA) Others

    IL13RA1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL13RA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IL13RA1 Human Pre-designed siRNA Set A
    IL13RA1 Human Pre-designed siRNA Set A
  • HY-RS06737

    Small Interfering RNA (siRNA) Others

    IL22RA1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL22RA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IL22RA1 Human Pre-designed siRNA Set A
    IL22RA1 Human Pre-designed siRNA Set A
  • HY-P99782

    TNF Receptor Inflammation/Immunology
    Opinercept is a tumor necrosis factor-alpha (TNF-alpha) inhibitor. Opinercept can be used for the research of rheumatoid arthritis (RA) .
    Opinercept
  • HY-149064

    Bacterial Infection
    Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra .
    Antituberculosis agent-9
  • HY-P99210

    CDP 6038; OKZ

    Interleukin Related Inflammation/Immunology
    Olokizumab (CDP 6038) is a humanized monoclonal antibody targeting the interleukin-6 (IL-6). Olokizumab can be used in research of rheumatoid arthritis (RA) .
    Olokizumab
  • HY-164416

    Others Inflammation/Immunology
    DBCO-Dextran sulfate (MW 40000) can be used to construct DS-EXOs in cells via click chemistry, that can be used for the research of rheumatoid arthritis (RA) .
    DBCO-Dextran sulfate (MW 40000)
  • HY-P99642

    MOrAb-022

    c-Fms SARS-CoV Infection Inflammation/Immunology
    Gimsilumab (MORAb-022) is a human anti-GM-CSF monoclonal antibody. Gimsilumab has the potential for the research of COVID-19 and rheumatoid arthritis (RA) .
    Gimsilumab
  • HY-P99870

    ASLAN004; CSL-334

    Interleukin Related Others
    Eblasakimab (ASLAN004; CSL-334) is a human IgG4 antibody that specifically targets IL13RA1 and is primarily expressed by CHO-K1 cells [1].
    Eblasakimab
  • HY-167905

    Adenosine Receptor Neurological Disease
    ATL444 is a adenosine receptor antagonist, with Ki values of 7.0, 2.5, 61.8, >1000 nM for rA1AR, rA2AAR, rA2BAR, rA3AR, respectively [1].
    ATL444
  • HY-N2876

    Parasite Bacterial Infection
    Anisofolin A is a flavonoid that can be isolated from Anisomeles indica. Anisofolin A has antimalarial activity (IC50: 4.39 μM), and antimycobacterium activity (IC50: 4.50 μM) against M. tuberculosis H37Ra .
    Anisofolin A
  • HY-125415

    PGE synthase Inflammation/Immunology
    PF-4693627 is a potent, selective and orally bioavailable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor (IC50=3 nM) for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA) .
    PF-4693627
  • HY-N11646

    Bacterial Infection
    Ganorbiformin B is a lanostane triterpenoid. Ganorbiformin B shares the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T exhibits potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra .
    Ganorbiformin B
  • HY-P99790

    CEN 000029; cM-T412

    Transmembrane Glycoprotein Inflammation/Immunology
    Priliximab (CEN 000029) is an anti-CD4 humanized monoclonal antibody. Priliximab binds to CD4 on the surface of T cells, resulting in a significant and sustained reduction in circulating CD4 + T cells. Priliximab can be used in research of rheumatoid arthritis (RA) .
    Priliximab
  • HY-P99287

    B-E8; Anti-IL-6 MAB B-E8; Anti-Human IL6 Recombinant Antibody

    Interleukin Related Inflammation/Immunology Cancer
    Elsilimomab (B-E8) is a IgG1 monoclonal antibody against interleukin-6 (IL-6), with a KD of 22 pM and an IC50 of 1.4 nM. Elsilimomab can be used for the research of multiple myeloma, renal cell carcinoma, and rheumatoid arthritis (RA) .
    Elsilimomab
  • HY-110159

    (E/Z)-A77 1726

    Dihydroorotate Dehydrogenase Infection Inflammation/Immunology
    (E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA) .
    (E/Z)-Teriflunomide
  • HY-125068

    Cytochrome P450 p38 MAPK Inflammation/Immunology
    RPR203494 is a potent inhibitor against CYP isozymes. RPR203494 shows inhibition against p38 kinase with an IC50 value of 9 nM and an EC50 value of 60 nM. RPR203494 demonstrates an inhibition of hepatic Cytochrome P450. RPR203494 is promising for research of rheumatoid arthritis (RA) .
    RPR203494
  • HY-P99487

    BR 3FC

    ADC Antibody Inflammation/Immunology
    Briobacept (BR 3FC) is a selective human monoclonal antibody targeting to BLyS (BAFF), induces B cells apoptosis. Briobacept is a recombinant glucoprotein, consists of 2 molecules from the BLyS receptor (BR3)and a Fc domain of human IgG1. Briobacept can be used in studies of rheumatoid arthritis (RA) .
    Briobacept
  • HY-155031

    Reactive Oxygen Species COX Inflammation/Immunology Cancer
    MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA) .
    MCI
  • HY-118530

    SA96; Thiobutarit

    VEGFR Cardiovascular Disease Inflammation/Immunology
    Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
    Bucillamine
  • HY-151472

    Carbonic Anhydrase Infection
    hCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) .
    hCAIX/XII-IN-6
  • HY-118530R

    VEGFR Cardiovascular Disease Inflammation/Immunology
    Bucillamine (Standard) is the analytical standard of Bucillamine. This product is intended for research and analytical applications. Bucillamine (SA96) is an orally active and potent sulfhydryl donor and antioxidant. Bucillamine is also an antirheumatic agent with antiangiogenic properties. Bucillamine can protect against Ischemia/reperfusion (I/R) injury in high-risk organ transplants. Bucillamine inhibits the production of VEGF. Bucillamine can be used for the research of choroidal neovascularization (CNV) and rheumatoid arthritis (RA) .
    Bucillamine (Standard)
  • HY-N1976
    (+)-(3R,8S)-Falcarindiol
    1 Publications Verification

    (3R,8S)-Falcarindiol; 3(R),8(S),9(Z)-Falcarindiol

    Bacterial Infection Inflammation/Immunology Cancer
    (+)-(3R,8S)-Falcarindiol is a polyacetylene found in carrots, has antimycobacterial activity, with an IC50 of 6 μM and MIC of 24 μM against Mycobacterium tuberculosis H37Ra . Antineoplastic and anti-inflammatory activity . (+)-(3R,8S)-Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (+)-(3R,8S)-Falcarindiol
  • HY-118761

    5,6-epoxy atrA; 5,6-epoxy rA

    Others Metabolic Disease
    all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s=77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). 5,6-epoxy RA (1 μM) also induces growth arrest of MCF-7 and NB4 cells in vitro. It is a natural metabolite of all-trans retinoic acid, which is a metabolite of vitamin A.
    5,6-Epoxyretinoic acid
  • HY-N2435
    [8]-Shogaol
    1 Publications Verification

    COX Apoptosis Cancer
    [8]-Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC50=5 μM), anti-cancer and anti-inflammatory activity. [8]-Shogaol inhibited COX-2 (IC50=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC50=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA) .
    [8]-Shogaol
  • HY-N2435R

    COX Apoptosis Cancer
    -Shogaol (Standard) is the analytical standard of -Shogaol. This product is intended for research and analytical applications. -Shogaol, a kind of stimulating compound in ginger, has antiplatelet (IC50=5 μM), anti-cancer and anti-inflammatory activity. -Shogaol inhibited COX-2 (IC50=17.5 μM), which led to the decline of human leukemia cells. 8-Shogaol Selective direction TAK1 sum TAK1-TAB1 (IC50=5 μM), suppress IKK, Akt sum MAPK signal pathway, and reverse synovitis synovial sum Air dampness (RA) .
    [8]-Shogaol (Standard)

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