IL-13R alpha 1 Protein, Human (HEK293, His)

The IL13RA1 protein is critical in immune signaling and binds with low affinity to IL13. It binds to IL4RA to form a functional IL13 receptor for cellular responses. IL-13R alpha 1 Protein, Human (HEK293, His) is the recombinant human-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-6*His labeled tag.

The IL13RA1 protein plays a vital role in immune signaling, exhibiting low-affinity binding to interleukin-13 (IL13). When partnered with IL4RA, it forms a functional receptor for IL13, facilitating the cellular response to this cytokine. Additionally, IL13RA1 serves as an alternate accessory protein alongside IL4RA for interleukin-4 (IL4) signaling, although it cannot replace the function of IL2RG in enhancing interleukin-2 (IL2) binding activity. The interleukin-13 receptor is a complex assembly comprising IL4R, IL13RA1, and possibly other components, indicating the intricate architecture of this signaling system. Moreover, IL13RA1 interacts with TRAF3IP1, suggesting its involvement in diverse cellular processes. Furthermore, IL13RA1 engages in interactions with IL4, underlining its multifaceted role in mediating responses to interleukin signaling pathways.

Human

HEK293

C-6*His

P78552-1 (G22-T343)

3597  [NCBI]

GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST

55-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.