2. Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase
  4. (E/Z)-Teriflunomide

(E/Z)-Teriflunomide  (Synonyms: (E/Z)-A77 1726)

Cat. No.: HY-110159 Purity: ≥95.0%
COA Handling Instructions

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(E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA).

For research use only. We do not sell to patients.

(E/Z)-Teriflunomide Chemical Structure

(E/Z)-Teriflunomide Chemical Structure

CAS No. : 108605-62-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 28 In-stock
Solution
10 mM * 1 mL in DMSO USD 28 In-stock
Solid
25 mg USD 26 In-stock
50 mg USD 40 Get quote
100 mg USD 60 Get quote
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of (E/Z)-Teriflunomide:

(E/Z)-Teriflunomide Related Antibodies

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  • Purity & Documentation

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Description

(E/Z)-Teriflunomide ((E/Z)-A77 1726) is the active metabolite of Leflunomide (HY-B0083). Leflunomide is an immunomodulatory agent that may exert effects by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH). Leflunomide can be used for the research of rheumatoid arthritis (RA)[1].

Molecular Weight

270.21

Formula

C12H9F3N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (185.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7008 mL 18.5041 mL 37.0083 mL
5 mM 0.7402 mL 3.7008 mL 7.4017 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (246 KB) HNMR (121 KB) LCMS (291 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7008 mL 18.5041 mL 37.0083 mL 92.5206 mL
5 mM 0.7402 mL 3.7008 mL 7.4017 mL 18.5041 mL
10 mM 0.3701 mL 1.8504 mL 3.7008 mL 9.2521 mL
15 mM 0.2467 mL 1.2336 mL 2.4672 mL 6.1680 mL
20 mM 0.1850 mL 0.9252 mL 1.8504 mL 4.6260 mL
25 mM 0.1480 mL 0.7402 mL 1.4803 mL 3.7008 mL
30 mM 0.1234 mL 0.6168 mL 1.2336 mL 3.0840 mL
40 mM 0.0925 mL 0.4626 mL 0.9252 mL 2.3130 mL
50 mM 0.0740 mL 0.3701 mL 0.7402 mL 1.8504 mL
60 mM 0.0617 mL 0.3084 mL 0.6168 mL 1.5420 mL
80 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1565 mL
100 mM 0.0370 mL 0.1850 mL 0.3701 mL 0.9252 mL
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(E/Z)-Teriflunomide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Teriflunomide108605-62-5(E/Z)-A77 1726Dihydroorotate DehydrogenaseDHODHactive metaboliteLeflunomideimmunomodulatorydihydroorotate dehydrogenase (DHODH)rheumatoid arthritis (RA)Inhibitorinhibitorinhibit

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