2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species COX
  4. MCI

MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA).

For research use only. We do not sell to patients.

MCI Chemical Structure

MCI Chemical Structure

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MCI Related Antibodies

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COX COX-1 COX-2 COX-3

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Description

MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA)[1].

IC50 & Target[1]

COX-2

1.23 μM (IC50)

In Vitro

MCI (8 μM, 2 h) inhibits ROS production and COX-2 expression results in the phenotypic transition of macrophages from the M1 state to the M2 state in the LPS-stimulated RAW 264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCI Related Antibodies

Immunofluorescence[1]

Cell Line: LPS-stimulated RAW 264.7 cell
Concentration: 8 μM
Incubation Time: 2 h
Result: Inhibited the level of NF-κB p65 in the nuclei.
Increased the level of CD163.

Western Blot Analysis[1]

Cell Line: LPS-stimulated RAW 264.7 cell
Concentration: 8 μM
Incubation Time: 2 h
Result: Inhibited COX-2 and iNOS expression.
Increased arginase-1 (Arg-1) expression.
In Vivo

MCI (1.05 mg/kg, intraarticularly injection, once every three days for 18 days) prevents the progression of RA and has significant anti-inflammatory effects[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Collagen-induced arthritis (CIA) models with BALB/c mice[1]
Dosage: 1.05 mg/kg, once every three days for 18 days
Administration: Intraarticularly injection
Result: Reduced the average ankle thickness and clinical index.
Reduced cartilage damage and essentially intact like that of healthy mice.
Clinical Trial
Molecular Weight

934.39

Formula

C45H52ClN7O13
SMILES

O[C@H]1[C@H](O)[C@H](CO)OC(OCCN2C=C(C[C@H](NC(/C=C/C3=CC(O)=C(O)C=C3)=O)C(NCCCCNC(CC4=C(C)N(C(C5=CC=C(Cl)C=C5)=O)C6=CC=C(OC)C=C46)=O)=O)N=N2)[C@H]1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MCI Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCIReactive Oxygen SpeciesCOXCyclooxygenaseRAW 264.7macrophageM1M2collagen-induced arthritis (CIA) modelsrheumatoid arthritis (RA)Inhibitorinhibitorinhibit

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