Briobacept  (Synonyms: BR 3FC)

Briobacept (BR 3FC) is a recombinant glucoprotein, consists of 2 molecules from the BLyS receptor (BR3)and a Fc domain of human IgG1. Briobacept selectively targets to BLyS (BAFF), induces B cells apoptosis. Briobacept can be used in studies of rheumatoid arthritis (RA)^[1][2].

Human

BLyS (BAFF)^[1]

Briobacept blocks circulating BLyS, thus inhibiting B cell activation and promoting B cell apoptosis^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Briobacept (100 μg/mouse; i.p.; for 5 d) inhibits basal NF-κB2 activation in wild-type mice^[4].
Briobacept (100 μg/mouse; i.p.; 3 times per week for 5 weeks) inhibits p52 generation and development of spontaneous lupus-like disease in NZB/WF1 mice^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

869881-54-9

Liquid

Colorless to light yellow

[Briobacept]

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  [TNFRSF13C (tumor necrosis factor receptor (TNFR)superfamily member 13C, BAFFR, BR3, B cell activating factor receptor, CD268)]2-IGHG1 Fc (Fragment constant)

• [1]. Sifuentes Giraldo WA, et al. New targets in systemic lupus (part 2/2). Reumatol Clin. 2012 Sep-Oct;8(5):263-9.  [Content Brief]

  [2]. Liu Yunjie, et al. Research progress on the pathogenesis and drug targeting therapy of B lymphocyte stimulator-induced rheumatoid arthritis. 2011;22(33):3152-3154.

  [3]. La Cava A. Targeting B cells with biologics in systemic lupus erythematosus. Expert Opin Biol Ther. 2010 Nov;10(11):1555-61.  [Content Brief]

  [4]. Kayagaki N, et al. BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2. Immunity. 2002 Oct;17(4):515-24.  [Content Brief]