2. Immunology/Inflammation Anti-infection
  3. Toll-like Receptor (TLR) SARS-CoV
  4. SMU-CX1

SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5.

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SMU-CX1 Chemical Structure

SMU-CX1 Chemical Structure

CAS No. : 10371-86-5

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SMU-CX1 Related Antibodies

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Description

SMU-CX1 is a specific TLR3 inhibitor (IC50: 0.11 μM) with IC50 ranging from 0.14-0.33 μM against multiple influenza A virus subtypes. SMU-CX1 inhibits the viral PB2 and NP proteins with an IC50 of 0.43 μM for SARS-CoV-2 activity. SMU-CX1 also inhibits inflammatory factors in host cells, including IFN-β, IP-10, and CCL-5[1].

Molecular Weight

276.33

Formula

C18H16N2O
CAS No.
SMILES

COC1=CC=C2C(C(C(C)=C3C(C=CN=C3)=C4C)=C4N2)=C1
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMU-CX1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMU-CX110371-86-5Toll-like Receptor (TLR)SARS-CoVSARS coronavirusAnti-inflammatoryInfluenza A virusSARS-CoV-2Small moleculeInhibitorinhibitorinhibit

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