SPV106

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SPV106 is histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT) activator. SPV106 can be used for the research of type 2 diabetes (T2D).

For research use only. We do not sell to patients.

SPV106 Chemical Structure

CAS No. : 1036939-38-4

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Biological Activity
Purity & Documentation
References
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Description

SPV106 is histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT) activator. SPV106 can be used for the research of type 2 diabetes (T2D)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
U-937	IC₅₀	44.91 μM Compound: 1b	Induction of apoptosis in human U937 cells after 30 hrs using annexin V/propidium iodide double-staining by FACS analysis Induction of apoptosis in human U937 cells after 30 hrs using annexin V/propidium iodide double-staining by FACS analysis	[PMID: 21292492]

In Vitro

SPV106 restores normal levels of H3K9Ac and H3K14Ac, reduces DNA CpG hypermethylation, and recovers D-CMSC proliferation and differentiation^[1].
SPV106 (5 µmol/L) reduces cellular senescence and induces cKit expression in D-CMSC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Human cardiac-specific mesenchymal cell (CMSC)
Concentration:	25 μmol/L
Incubation Time:	6-8 days
Result:	Achieved partial but significant rescue of HAT activity.

RT-PCR^[1]

Cell Line:	Human cardiac-specific mesenchymal cell (CMSC)
Concentration:	25 μmol/L
Incubation Time:	7 days
Result:	Not associated to a rescue in gene transcription.

Molecular Weight

368.55

Formula

C₂₂H₄₀O₄

CAS No.

1036939-38-4

SMILES

O=C(OCC)/C(C(OCC)=O)=C/CCCCCCCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matteo Vecellio, et al. The histone acetylase activator pentadecylidenemalonate 1b rescues proliferation and differentiation in the human cardiac mesenchymal cells of type 2 diabetic patients. Diabetes. 2014 Jun;63(6):2132-47. [Content Brief]

SPV106 Related Classifications

Metabolic Disease

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPV1061036939-38-4SPV 106SPV-106Histone AcetyltransferaseHATsHAThistone acetylase (HAT)GCN5-related N-acetyltransferases (GNAT)type 2 diabetes (T2D)Inhibitorinhibitorinhibit

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