Sulfo-LC-SPDP sodium

Name: Sulfo-LC-SPDP sodium
Brand: MedChemExpress
SKU: HY-126495A
Rating: 4.5 (1 reviews)

Cat. No.: HY-126495A Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Sulfo-LC-SPDP sodium Chemical Structure

CAS No. : 169751-10-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Sulfo-LC-SPDP sodium:

Sulfo-LC-SPDP Get quote

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•Related Small Molecules:

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View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

Biological Activity
Purity & Documentation
References
Customer Review

Description

Sulfo-LC-SPDP sodium is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Disulfide Cleavable Linker

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

527.57

Formula

C₁₈H₂₂N₃NaO₈S₃

CAS No.

169751-10-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCCNC(CCSSC2=NC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (94.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8955 mL	9.4774 mL	18.9548 mL
5 mM	0.3791 mL	1.8955 mL	3.7910 mL
10 mM	0.1895 mL	0.9477 mL	1.8955 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (245 KB) HNMR (135 KB) LCMS (225 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8955 mL	9.4774 mL	18.9548 mL	47.3871 mL
	5 mM	0.3791 mL	1.8955 mL	3.7910 mL	9.4774 mL
	10 mM	0.1895 mL	0.9477 mL	1.8955 mL	4.7387 mL
	15 mM	0.1264 mL	0.6318 mL	1.2637 mL	3.1591 mL
	20 mM	0.0948 mL	0.4739 mL	0.9477 mL	2.3694 mL
	25 mM	0.0758 mL	0.3791 mL	0.7582 mL	1.8955 mL
	30 mM	0.0632 mL	0.3159 mL	0.6318 mL	1.5796 mL
	40 mM	0.0474 mL	0.2369 mL	0.4739 mL	1.1847 mL
	50 mM	0.0379 mL	0.1895 mL	0.3791 mL	0.9477 mL
	60 mM	0.0316 mL	0.1580 mL	0.3159 mL	0.7898 mL
	80 mM	0.0237 mL	0.1185 mL	0.2369 mL	0.5923 mL