Tubulin inhibitor 26

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Tubulin inhibitor 26 (compound 3c) is a potent inhibitor of tubulin. Tubulin inhibitor 26 is an indazole derivative compound. Tubulin inhibitor 26 shows noteworthy low nanomolar potency against HepG2, HCT116, SW620, HT29 and A549 cancer cell lines. Tubulin inhibitor 26 arrests tumor cell in G2/M phase and induced cell apoptosis. Tubulin inhibitor 26 suppresses tumor growth in vivo without affecting the mice body weight.

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Tubulin inhibitor 26 Chemical Structure

CAS No. : 2379241-70-8

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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.033 μM Compound: 3c	Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HCT-116	GI₅₀	0.015 μM Compound: 3c	Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HepG2	GI₅₀	0.027 μM Compound: 3c	Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HT-29	GI₅₀	0.031 μM Compound: 3c	Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
HUVEC	GI₅₀	> 25 μM Compound: 3c	Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against HUVEC assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]
SW-620	GI₅₀	0.008 μM Compound: 3c	Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay Antiproliferative activity against human SW-620 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 31865012]

Molecular Weight

313.35

Formula

C₁₇H₁₉N₃O₃

CAS No.

2379241-70-8

SMILES

COC1=CC(NC2=NNC3=CC(C)=CC=C32)=CC(OC)=C1OC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cui YJ, et al. The discovery of novel indazole derivatives as tubulin colchicine site binding agents that displayed potent antitumor activity both in vitro and in vivo. Eur J Med Chem. 2020;187:111968 [Content Brief]