Veratridine (Synonyms: 3-Veratroylveracevine)

Name: Veratridine
Brand: MedChemExpress
SKU: HY-N6691
Rating: 5.0 (3 reviews)

Cat. No.: HY-N6691 Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Veratridine (3-Veratroylveracevine) is a plant neurotoxin, a voltage-gated sodium channels (VGSCs) agonist. Veratridine inhibits the peak current of Nav1.7, with an IC₅₀ of 18.39 µM. Veratridine regulates sodium ion channels mainly by activating sodium ion channels, preventing channel inactivation and increasing sodium ion flow.

For research use only. We do not sell to patients.

Veratridine Chemical Structure

CAS No. : 71-62-5

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 178	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 178	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 570	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Veratridine:

Veratridine (Standard) Get quote

3 Publications Citing Use of MCE Veratridine

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•Related Screening Libraries:

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View All Sodium Channel Isoform Specific Products:

View All Isoforms

Na_v1.1 Na_v1.2 Na_v1.3 Na_v1.4 Na_v1.5 Na_v1.6 Na_v1.7 Na_v1.8

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Na_v1.7

18.39 μM (IC₅₀)

In Vitro

Veratridine (0.25 mM and 1 mM; 24 h) treatment results in all cells death^[2].
Veratridine (0.001-100 μM) produces tetrodotoxin-sensitive responses^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:	Neuro-2a cells
Concentration:	0.25 mM and 1 mM
Incubation Time:	24 hours
Result:	Caused around 100% cell mortality (0% cell viability).

Cell Viability Assay^[3]

Cell Line:	Cultured mouse DRG neurons
Concentration:	0.001, 0.1, 1, 10, 30, and 100 μM
Incubation Time:
Result:	Increased responding neurons number from a threshold of 1 μM in a concentration-dependent manner.

Molecular Weight

673.79

Formula

C₃₆H₅₁NO₁₁

CAS No.

71-62-5

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@]34[C@](CC[C@]1([H])[C@@](O)([C@@H](OC(C5=CC(OC)=C(OC)C=C5)=O)CC2)O4)([H])[C@@]6(O)[C@](O)([C@@]7([H])[C@@](O)([C@](O)([C@@]8([H])N(C[C@@H](C)CC8)C7)C)[C@@H](O)C6)C3

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (148.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4841 mL	7.4207 mL	14.8414 mL
5 mM	0.2968 mL	1.4841 mL	2.9683 mL
10 mM	0.1484 mL	0.7421 mL	1.4841 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.71 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (281 KB) SDS (587 KB)

COA (259 KB) HNMR (315 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724. [Content Brief]

[2]. Laura A Uribe, et al. Supramolecular Complexes of Plant Neurotoxin Veratridine with Cyclodextrins and Their Antidote-like Effect on Neuro-2a Cell Viability. Pharmaceutics. 2022 Mar 9;14(3):598. [Content Brief]

[3]. Zainab A Mohammed, et al. Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Sci Rep. 2017 Mar 24;7:45221. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4841 mL	7.4207 mL	14.8414 mL	37.1035 mL
	5 mM	0.2968 mL	1.4841 mL	2.9683 mL	7.4207 mL
	10 mM	0.1484 mL	0.7421 mL	1.4841 mL	3.7104 mL
	15 mM	0.0989 mL	0.4947 mL	0.9894 mL	2.4736 mL
	20 mM	0.0742 mL	0.3710 mL	0.7421 mL	1.8552 mL
	25 mM	0.0594 mL	0.2968 mL	0.5937 mL	1.4841 mL
	30 mM	0.0495 mL	0.2474 mL	0.4947 mL	1.2368 mL
	40 mM	0.0371 mL	0.1855 mL	0.3710 mL	0.9276 mL
	50 mM	0.0297 mL	0.1484 mL	0.2968 mL	0.7421 mL
	60 mM	0.0247 mL	0.1237 mL	0.2474 mL	0.6184 mL
	80 mM	0.0186 mL	0.0928 mL	0.1855 mL	0.4638 mL
	100 mM	0.0148 mL	0.0742 mL	0.1484 mL	0.3710 mL

Veratridine Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veratridine71-62-53-VeratroylveracevineSodium ChannelNa channelsNa+ channelsLiliaceaeNav1.7voltage-gated sodium channelsNeuro-2aDRG neuronsInhibitorinhibitorinhibit

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Veratridine (Synonyms: 3-Veratroylveracevine)

Customer Review

Other Forms of Veratridine:

Veratridine Related Antibodies

3 Publications Citing Use of MCE Veratridine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Sodium Channel Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Veratridine Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Veratridine Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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