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2-MNG  (Synonyms: 2-Mercaptonicotinoyl glycine)

Cat. No.: HY-159107 Purity: 98.04%
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2-MNG (2-Mercaptonicotinoyl glycine) is an inhibitor for melanogenesis with an average IC50 of 49.5μM in normal human melanocytes. 2-MNG binds to melanin precursors, prevents the incorporation into growing melanin, and thereby inhibits the synthesis of eumelanin and pheomelanin. 2-MNG can be used in research about skin pigmentation.

For research use only. We do not sell to patients.

2-MNG Chemical Structure

2-MNG Chemical Structure

CAS No. : 2101538-28-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 127 In-stock
Solution
10 mM * 1 mL in DMSO USD 127 In-stock
Solid
5 mg USD 116 In-stock
10 mg USD 185 In-stock
25 mg USD 372 In-stock
50 mg USD 595 In-stock
100 mg USD 950 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

2-MNG Related Antibodies

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Description

2-MNG (2-Mercaptonicotinoyl glycine) is an inhibitor for melanogenesis with an average IC50 of 49.5μM in normal human melanocytes. 2-MNG binds to melanin precursors, prevents the incorporation into growing melanin, and thereby inhibits the synthesis of eumelanin and pheomelanin. 2-MNG can be used in research about skin pigmentation[1].

Molecular Weight

212.23

Formula

C8H8N2O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CNC(C1=CC=CNC1=S)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (549.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7119 mL 23.5593 mL 47.1187 mL
5 mM 0.9424 mL 4.7119 mL 9.4237 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7119 mL 23.5593 mL 47.1187 mL 117.7967 mL
5 mM 0.9424 mL 4.7119 mL 9.4237 mL 23.5593 mL
10 mM 0.4712 mL 2.3559 mL 4.7119 mL 11.7797 mL
15 mM 0.3141 mL 1.5706 mL 3.1412 mL 7.8531 mL
20 mM 0.2356 mL 1.1780 mL 2.3559 mL 5.8898 mL
25 mM 0.1885 mL 0.9424 mL 1.8847 mL 4.7119 mL
30 mM 0.1571 mL 0.7853 mL 1.5706 mL 3.9266 mL
40 mM 0.1178 mL 0.5890 mL 1.1780 mL 2.9449 mL
50 mM 0.0942 mL 0.4712 mL 0.9424 mL 2.3559 mL
60 mM 0.0785 mL 0.3927 mL 0.7853 mL 1.9633 mL
80 mM 0.0589 mL 0.2945 mL 0.5890 mL 1.4725 mL
100 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1780 mL
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2-MNG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-MNG2101538-28-52-Mercaptonicotinoyl glycineOthersMelanogenesisskin pigmentationmelanocyteInhibitorinhibitorinhibit

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