2. Anti-infection
  3. Bacterial Antibiotic
  4. Delafloxacin

Delafloxacin  (Synonyms: RX-3341; WQ-3034; ABT492)

Cat. No.: HY-14814 Purity: 99.84%
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Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia.

For research use only. We do not sell to patients.

Delafloxacin Chemical Structure

Delafloxacin Chemical Structure

CAS No. : 189279-58-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 35 In-stock
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10 mM * 1 mL in DMSO USD 35 In-stock
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50 mg USD 200 In-stock
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Based on 2 publication(s) in Google Scholar

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Delafloxacin Related Antibodies

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Description

Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1].

IC50 & Target

Quinolone

 

In Vivo

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log10 CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log10 kill from initial burden for all S. aureus strains[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae, and four K. pneumoniae strains)[1]
Dosage: The total daily doses vary from 0.156 to 640 mg/kg/24 h
Administration: 0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
Result: Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively.
Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively.
Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.
Animal Model: Neutropenic mice[1]
Dosage: 2.5, 10, 40, and 160 mg/kg; 0.2 mL
Administration: Subcutaneous injection; 24 h
Result: The maximum drug concentrations (Cmax) concentrations ranged from 2 to 71 mg/L. AUC0-∞ values ranged from 2.8 to 152 mg•h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t1/2) ranged from 0.7 to 1 h.
Clinical Trial
Molecular Weight

440.76

Formula

C18H12ClF3N4O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CN(C2=NC(N)=C(F)C=C2F)C3=C(C=C(F)C(N4CC(O)C4)=C3Cl)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (226.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2688 mL 11.3440 mL 22.6881 mL
5 mM 0.4538 mL 2.2688 mL 4.5376 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2688 mL 11.3440 mL 22.6881 mL 56.7202 mL
5 mM 0.4538 mL 2.2688 mL 4.5376 mL 11.3440 mL
10 mM 0.2269 mL 1.1344 mL 2.2688 mL 5.6720 mL
15 mM 0.1513 mL 0.7563 mL 1.5125 mL 3.7813 mL
20 mM 0.1134 mL 0.5672 mL 1.1344 mL 2.8360 mL
25 mM 0.0908 mL 0.4538 mL 0.9075 mL 2.2688 mL
30 mM 0.0756 mL 0.3781 mL 0.7563 mL 1.8907 mL
40 mM 0.0567 mL 0.2836 mL 0.5672 mL 1.4180 mL
50 mM 0.0454 mL 0.2269 mL 0.4538 mL 1.1344 mL
60 mM 0.0378 mL 0.1891 mL 0.3781 mL 0.9453 mL
80 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7090 mL
100 mM 0.0227 mL 0.1134 mL 0.2269 mL 0.5672 mL
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Delafloxacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delafloxacin189279-58-1RX-3341 WQ-3034 ABT492RX3341RX 3341WQ3034WQ 3034WQ-3034ABT492ABT 492ABT-492BacterialAntibioticInhibitorinhibitorinhibit

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