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  6. Anti-Drug-Resistant Compound Library
Anti-Drug-Resistant Compound Library

Cat. No.: HY-L169

Resistance refers to the decrease in the effectiveness of drugs in treating diseases or symptoms. Due to the increasing global antibiotic resistance, it may threaten our ability to treat common infectious diseases. Drug resistance is also the main cause of chemotherapy failure in malignant tumors. In approximately 50% of cases, drug resistance exists even before chemotherapy begins. There are many mechanisms of anticancer drug resistance, including increased protein expression that leads to drug removal, mutations in drug binding sites, recovery of tumor protein production, and pre-existing genetic heterogeneity in tumor cell populations. In addition, the issue of drug resistance seems to have affected the development of new anticancer drugs. Drug resistance may be caused by various conditions, such as mutations, epigenetic modifications, and upregulation of drug efflux protein expression. Overcoming multidrug resistance in cancer treatment is becoming increasingly important.

MCE designs a unique collection of 435 anti-drug-resistant compounds. It is a good tool to be used for research on cancer and other diseases.

For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Description & Advantages

•   A unique collection of 435 anti-drug-resistant compounds for high throughput screening (HTS) and high content screening (HCS).

•   A useful tool for cancer and other diseases research.

•   Structurally diverse, medicinally active and cell permeable.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some compounds have been approved by FDA.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   High purity and quality validated by NMR and LC/MS.

Product Details

Formulation:

A collection of 435 anti-drug-resistant compounds supplied as pre-dissolved Solutions or Solid
Solution: 425 compounds supplied in 10 mM solution, 8 compounds supplied in 2 mM solution, 2 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

Composition

BCRP (16)

EGFR (13)

HIV (11)

CFTR (10)

HBV (8)

CDK (7)

HCV (6)

HSP (6)

STAT (6)

MMP (5)

mTOR (5)

PARP (5)

AMPK (4)

HDAC (4)

PPAR (4)

Akt (3)

ERK (3)

JNK (3)

BCL6 (2)

Btk (2)

CMV (2)

COX (2)

CXCR (2)

FGFR (2)

FLT3 (2)

HSV (2)

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Compound Customization
  •  Specific Compounds
  •  Quantities
  •  Plate Map
  •  Concentration
  •  Form (Solid or Solution)
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    Product Name:
    Anti-Drug-Resistant Compound Library
    Cat. No.:
    HY-L169
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack

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