2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    Neuronal Signaling
  4. FAAH

FAAH

Fatty acid amide hydrolase

FAAH

Related Products

PDF 0.4 MB

FAAH (Fatty acid amide hydrolase) is a membrane-bound protein belonging to serine hydrolase family of enzymes.FAAH is responsible for the hydrolysis of a number of important endogenous fatty acid amides, including the endogenous cannabimimetic agent anandamide (AEA), the sleep-inducing compound oleamide, and the putative anti-inflammatory agent palmitoylethanolamide (PEA). FAAH plays a significant role in termination of signalling of a class of bioactive lipids called fatty acid amides (FAAs) both in the central nervous system (CNS) and peripheral tissues.

FAAH belongs to the amidase signature (AS) superfamily and is widely distributed in multicellular eukaryotes. FAAH has a key role in the control of the cannabinoid signaling, through the hydrolysis of the endocannabinoids anandamide and in some tissues 2-arachidonoylglycerol.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146341
    FAAH-IN-5
    		Inhibitor
    FAAH-IN-5 (Compound 7) is a relative selective, irreversible fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 10.5 nM. FAAH-IN-5 shows low PAMPA (Parallel Artificial Membrane Permeability Assay) permeability.
    FAAH-IN-5
  • HY-152251
    CB2R/FAAH modulator-1
    		Inhibitor
    CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production.
    CB2R/FAAH modulator-1
  • HY-139143
    WWL154
    		Inhibitor
    WWL154, an analog of JZL184 that maintains the SH-reactive p-nitrophenyl carbamate group, is a FAAH-4 inhibitor.
    WWL154
  • HY-W728451
    URB694
    		Inhibitor
    URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare 11C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.
    URB694
  • HY-121558
    JP104
    		Inhibitor
    JP104, a aryl carbamate, is an irreversible FAAH inhibitor with a pIC50 of ~8.
    JP104
  • HY-163733
    AKU-005
    		Inhibitor
    AKU-005 is a FAAH and MAGL dual inhibitor with IC50 values of 63, 389 nM for rat and human FAAH, respectively. AKU-005 has the potential for the research of trigeminal hyperalgesia.
    AKU-005
  • HY-147910
    Carpro-AM1
    		Inhibitor
    Carpro-AM1 is a dual-acting FAAH/substrate-selective COX inhibitor with an IC50 value of 94 nM for FAAH.
    Carpro-AM1
  • HY-122159
    MDPD
    		Activator
    MDPD is an Arabidopsis FAAH (AtFAAH) activator that can enhance the enzymatic activity of AtFAAH.
    MDPD
  • HY-12909
    MK-4409
    		Inhibitor
    MK-4409 is a potent oxazole FAAH inhibitor and can be used for the research of inflammatory and neuropathic pain.
    MK-4409
  • HY-168563
    BuChE-IN-15
    		Inhibitor
    BuChE-IN-15 (compound D12) is a selective BuChE/FAAH dual inhibitor with and show IC50 values of 81 and 400 nM for hBuChE and hFFAH, respectively. BuChE-IN-15 possesses good BBB penetration, and shows neuroprotection.BuChE-IN-15 can be used for study of Alzheimer.
    BuChE-IN-15
  • HY-164506
    NRMA-8
    		Modulator
    NRMA-8 is a brain-penetrant small molecule nuclear receptor modulator. NRMA-8 is promising for research of central nervous system disorders, including Alzheimer's disease, Parkinson's disease, demylenation disorders and glioblastomas.
    NRMA-8
  • HY-10869
    OL-135
    		Inhibitor
    OL-135 is a CNS penetrant, selective, and reversible of FAAH inhibitor. OL-135 exhibits analgesic activity.
    OL-135
  • HY-157132
    FAAH-IN-8
    		Inhibitor
    FAAH-IN-8 (compound 11) is a competitive inhibitor of FAAH with an IC50 value of 6.7 nM and a Ki value of 5 nM. FAAH-IN-8 has high blood-brain permeability and a significant antioxidant profile with no neurotoxicity.
    FAAH-IN-8
  • HY-103339
    VDM11
    		Inhibitor
    VDM11 is a potent and selective anandamide membrane transporter (AMT) inhibitor. VDM11 inhibits FAAH and MAGL and may act as an alternative FAAH substrate.
    VDM11
  • HY-139384
    FAAH inhibitor 2
    		Inhibitor
    FAAH inhibitor 2 (Compound 17b) is an irreversible fatty acid amide hydrolase (FAAH) inhibitor, with an IC50 of 0.153 μM.
    FAAH inhibitor 2
  • HY-B1227R
    Carprofen (Standard)
    		Inhibitor
    Carprofen (Standard) is the analytical standard of Carprofen. This product is intended for research and analytical applications. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively.
    Carprofen (Standard)
  • HY-120481
    JNJ-40413269
    		Inhibitor
    JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC50 of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats.
    JNJ-40413269
  • HY-111293
    Arachidonamide
    Arachidonamide is substrate of anandamide amidohydrolase.
    Arachidonamide
  • HY-121090
    FAAH-IN-9
    		Inhibitor
    FAAH-IN-9 (compoud 59) is an irreversible oleoyl inhibitor of FAAH with Ki of 0.02 nM.
    FAAH-IN-9
  • HY-77491
    FAAH/MAGL-IN-5
    		Inhibitor 99.17%
    AM6701 is a potent FAAH/MAGL inhibitor (equipotent inhibitory IC50: 1.2 nM) with neuroprotective effects.
    FAAH/MAGL-IN-5
Cat. No. Product Name / Synonyms Application Reactivity