URB694

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URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare ¹¹C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH.

For research use only. We do not sell to patients.

URB694 Chemical Structure

CAS No. : 904672-77-1

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Description

In Vivo

URB694 (0.3 mg/kg; i.p.) increases the time spent by HAB rats on the open arms compared to vehicle condition, without affecting overall locomotor activity^[1].
URB694 (0.3 mg/kg; i.p.) reduces isoproterenol hydrochloride (ISOP; HY-B0468)-induced arrhythmia occurrence in HAB rats, whereas it has no significant effects in NAB and LAB rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	5-month-old male Wistar rats (350-450 g) selectively bred for high (HAB) and low (LAB) anxiety-related behavior in the elevated plus-maze test or non-selected rats (NAB)^[1]
Dosage:	0.3 mg/kg
Administration:	Administered intraperitoneally to rats in a volume of 0.5 mL/kg
Result:	Significantly increased the time spent by HAB rats on the open arms. Had no effects on NABs’ and LABs’ behavioral performance in the elevated plus maze test.

Animal Model:	HAB, NAB and LAB rats^[1]
Dosage:	0.3 mg/kg
Administration:	Received the i.p. injection 30 min before ISOP (0.02 mg/kg)
Result:	Significantly reduced ISOP-induced arrhythmia occurrence in HAB rats compared to vehicle pretreatment condition. Had no significant effects in NAB and LAB rats.

Molecular Weight

311.37

Formula

C₁₉H₂₁NO₃

CAS No.

904672-77-1

SMILES

O=C(OC=1C=CC(O)=C(C1)C=2C=CC=CC2)NC3CCCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Carnevali L, et, al. Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety. Sci Rep. 2015 Dec 14:5:18218. [Content Brief]

[2]. Boileau I, et, al. Whole-body radiation dosimetry of 11C-carbonyl-URB694: a PET tracer for fatty acid amide hydrolase. J Nucl Med. 2014 Dec;55(12):1993-7. [Content Brief]

URB694 Related Classifications

Neurological Disease Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

URB694904672-77-1URB 694URB-694FAAHFatty acid amide hydrolaseantidepressantcardioprotectivepositron emission tomographyPETInhibitorinhibitorinhibit

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