1. Metabolic Enzyme/Protease Neuronal Signaling
  2. FAAH
  3. JNJ-40413269

JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC50 of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats.

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JNJ-40413269 Chemical Structure

JNJ-40413269 Chemical Structure

CAS No. : 1184847-16-2

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Description

JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC50 of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats[1].

IC50 & Target

IC50: 28 nM (hFAAH), 270 nM (rFAAH)[1]

Molecular Weight

393.79

Formula

C19H15ClF3N3O

CAS No.
SMILES

FC(F)(F)C1=CC=C(C2=NC=NC(NC[C@H](O)C3=CC=CC=C3)=C2)C=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JNJ-40413269
Cat. No.:
HY-120481
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