2. Metabolic Enzyme/Protease Neuronal Signaling
  3. FAAH
  4. JNJ-40413269

JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC50 of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats.

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JNJ-40413269 Chemical Structure

JNJ-40413269 Chemical Structure

CAS No. : 1184847-16-2

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Description

JNJ-40413269 is an inhibitor for FAAH, that inhibits human FAAH and rats FAAH with IC50 of 28 nM and 270 nM. JNJ-40413269 exhibits analgesic efficacy in rat spinal nerve ligation model and exhibits good pharmacokinetic characteristics in rats[1].

IC50 & Target

IC50: 28 nM (hFAAH), 270 nM (rFAAH)[1]
Molecular Weight

393.79

Formula

C19H15ClF3N3O
CAS No.
SMILES

FC(F)(F)C1=CC=C(C2=NC=NC(NC[C@H](O)C3=CC=CC=C3)=C2)C=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-40413269 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-404132691184847-16-2JNJ40413269JNJ 40413269FAAHFatty acid amide hydrolaseAnalgesicratInhibitorinhibitorinhibit

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