2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Endogenous Metabolite

Endogenous Metabolite

Endogenous Metabolite

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Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-18569S1
    3-Indoleacetic acid-d4
    3-Indoleacetic acid-d4 (Indole-3-acetic acid-d4; 3-IAA-d4) is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid (Indole-3-acetic acid) is the most common natural plant growth hormone of the auxin class. It can be added to cell culture medium to induce plant cell elongation and division.
    3-Indoleacetic acid-d<sub>4</sub>
  • HY-N0229S11
    L-Alanine-1-13C,15N
    L-Alanine-1-13C,15N is the 13C- and 15N-labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1-<sup>13</sup>C,<sup>15</sup>N
  • HY-113239S2
    (Rac)-Hydroxycotinine-d3
    (Rac)-Hydroxycotinine-d3 is deuterated labeled Hydroxycotinine (HY-113239). Hydroxycotinine is the main nicotine metabolite detected in smokers urine.
    (Rac)-Hydroxycotinine-d<sub>3</sub>
  • HY-W015114R
    L-2-Hydroxyglutaric acid (disodium) (Standard)
    L-2-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of L-2-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
    L-2-Hydroxyglutaric acid (disodium) (Standard)
  • HY-118295
    Pyrimidine-indole hybrid
    Pyrimidine-indole hybrid is a compound that inhibits ciliogenesis and has the activity of antagonizing the Hedgehog signaling pathway by destabilizing microtubules. Pyrimidine-indole hybrid exerts its biological effects by inhibiting ciliogenesis and deconstructing the stable form of α-tubulin. Pyrimidine-indole hybrid has shown its unique mechanism of action in in vitro cell experiments and zebrafish embryo models, interfering with microtubule dynamics.
    Pyrimidine-indole hybrid
  • HY-129099AR
    N-Desmethyltamoxifen (hydrochloride) (Standard)
    N-Desmethyltamoxifen (hydrochloride) (Standard)
  • HY-B1779S5
    Sucrose-13C6
    Sucrose-13C6 is the 13C labeled Sucrose[1]. Sucrose (D-(+)-Saccharose) is a disaccharide which is composed of two monosaccharides, glucose and fructose. Sucrose can be applied in some animal models, including metabolic disease, obesity, diet on preference, and diabetes, et al[2].
    Sucrose-<sup>13</sup>C<sub>6</sub>
  • HY-N1150S5
    Thymidine-2′-13C
    Thymidine-2′-13C is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]<
    Thymidine-2′-<sup>13</sup>C
  • HY-P3185
    beta-Galactose dehydrogenase
    beta-Galactose dehydrogenase can make conversion of galactose to galactonolactone and the concomitant reduction of NAD to the fluorescent NADH. beta-Galactose dehydrogenase can be used for the determination of galactose.
    beta-Galactose dehydrogenase
  • HY-76847R
    Chenodeoxycholic Acid (Standard)
    Chenodeoxycholic Acid (Standard) is the analytical standard of Chenodeoxycholic Acid. This product is intended for research and analytical applications. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
    Chenodeoxycholic Acid (Standard)
  • HY-107748A
    5'-Guanidinonaltrindole TFA
    5'-Guanidinonaltrindole TFA is a selective kappa-opioid receptor antagonist with significant opioid antagonist activity. 5'-Guanidinonaltrindole TFA exhibits 5 times the antagonistic potency of the prototypical kappa-opioid receptor antagonist norbinatorphimine in smooth muscle preparations, with a selectivity ratio exceeding 500 times. Binding and functional studies of 5'-Guanidinonaltrindole TFA showed pA(2) values comparable to smooth muscle data. 5'-Guanidinonaltrindole TFA is regarded as a potentially valuable pharmacological tool for studying opioids due to its high selectivity and potency.
    5'-Guanidinonaltrindole TFA
  • HY-W751961
    2'-Deoxyadenosine-155
    2'-Deoxyadenosine-15N5 is the 15N5-labeled version of 2'-Deoxyadenosine (HY-W040329). 2'-Deoxyadenosine is a nucleoside adenosine derivative that can pair with deoxythymidine in double-stranded DNA.
    2'-Deoxyadenosine-<sup>15</supN<sub>5</sub>
  • HY-112537A
    Dipotassium glucose-6-phosphate, 98%
    D-Glucose-6-phosphate dipotassium salt dihydrate is a glucose sugar phosphorylated at the hydroxy group on carbon 6.
    Dipotassium glucose-6-phosphate, 98%
  • HY-W010256S
    D-Xylulose-1-13C
    D-Xylulose-1-13C is the 13C labeled D-Xylulose. D-xylulose is a precursor of the pentiol D-arabi[1][2].
    D-Xylulose-1-<sup>13</sup>C
  • HY-113301R
    Hexacosanoic acid (Standard)
    Hexacosanoic acid (Standard) is the analytical standard of Hexacosanoic acid. This product is intended for research and analytical applications. Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis.
    Hexacosanoic acid (Standard)
  • HY-N0040R
    Ginsenoside Rb2 (Standard)
    Ginsenoside Rb2 (Standard) is the analytical standard of Ginsenoside Rb2. This product is intended for research and analytical applications. Ginsenoside Rb2 is one of the main bioactive components of ginseng extracts. Rb2 can upregulate GPR120 gene expression. Ginsenoside Rb2 has antiviral effects.
    Ginsenoside Rb2 (Standard)
  • HY-W015466S
    Acetylvaline-15N
    Acetylvaline-15N is the 15N-labeled Acetylvaline. Acetylvaline is an endogenous metabolite[1].
    Acetylvaline-<sup>15</sup>N
  • HY-N3686S
    D-Arabitol-13C
    D-Arabitol-13C is the 13C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu[1][2].
    D-Arabitol-<sup>13</sup>C
  • HY-B1659S1
    Glycerol-13C
    Glycerol-13C is the 13C labeled Glycerol. Glycerol is used in sample preparation and gel formation for polyacrylamide gel electrophoresis[1][2][3][4].
    Glycerol-<sup>13</sup>C
  • HY-P2918A
    Phosphoglucose isomerase, bacillus stearothermophilus
    Phosphoglucose isomerase, bacillus stearothermophilus is a highly conserved glycolytic and dimeric enzyme. Phosphoglucose isomerase, bacillus stearothermophilus catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
    Phosphoglucose isomerase, bacillus stearothermophilus
Cat. No. Product Name / Synonyms Application Reactivity