2. Signaling Pathways
  3. Epigenetics
  4. MicroRNA
  5. MicroRNA Modulator

MicroRNA Modulator

MicroRNA Modulators (4):

Cat. No. Product Name Effect Purity
  • HY-122575
    Aurintricarboxylic acid
    		Modulator
    Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 µM.
  • HY-119833
    Rubone
    		Modulator 99.1%
    Rubone, a chalcone analog, is a modulator of miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34a downstream targets.
  • HY-164053
    MicroRNA modulator-1
    		Modulator 99.58%
    MicroRNA modulator-1 (TABLE4 compound 1) is an oxadiazole miR-21 inhibitor with AC50 of 14.64 μM.
  • HY-164054
    MicroRNA modulator-2
    		Modulator 99.54%
    MicroRNA modulator-2 (TABLE4 compound 2) is an oxadiazole miR-21 inhibitor with AC50 of 16.48 μM.