Neurokinin Receptor Antagonist

Neurokinin Receptor Antagonists (83):

Cat. No.	Product Name	Effect	Purity

HY-P1017

MDL 29913	Antagonist
MDL 29913, a cyclic pseudopeptide, is a competitive NK₂ tachykinin receptor selective antagonist, with a pA₂ of 8.66.

HY-10053S

Maropitant-d₃	Antagonist
Maropitant-d₃ is the deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.

HY-P10619

[Tyr6,D-Phe7,D-His9]-Substance P (6-11)	Antagonist
[Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a tachykinin NK1 receptor antagonist that antagonizes Histamine (HY-B1204) induced hyperalgesia.

HY-P1276

Men 10376	Antagonist
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-105137

Lanepitant dihydrochloride	Antagonist
Lanepitant dihydrochloride (LY303870 dihydrochloride) is a non-peptide neurokinin-1 receptor antagonist. Lanepitant dihydrochloride has analgesic and anti-inflammatory activities.

HY-P3805

[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11)	Antagonist
[D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) is a potent neurokinin NK1 antagonist. [D-Pro4,D-Trp7,9,Nle11] Substance P (4-11) inhibits the effects of gold-protein-substance P (GPSP) and substance P (SP).

HY-14407AS

Fosaprepitant-d₄ dimeglumine	Antagonist
Fosaprepitant-d₄ (dimeglumine) is deuterium labeled Fosaprepitant (dimeglumine). Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].

HY-10051

GR203040	Antagonist
GR203040 is an orally active NK₁ receptor antagonist with a pK_i of 10.3. GR203040 shows potent antiemetic activity.

HY-145250

NK1 receptor antagonist 2	Antagonist
NK1 receptor antagonist 2 is a NK1 receptor antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss.

HY-P1278A

GR 64349 TFA	Antagonist
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively.

HY-106982

Ezlopitant	Antagonist
Ezlopitant (CJ-11,974) is a selective, non-peptidic neurokinin-1 (NK-1)-receptor antagonist. Ezlopitant inhibits both acute and delayed emetic reactions induced by Cisplatin (HY-17394) in ferrets via acting on NK1 receptors in the central nervous system. Ezlopitant has the potential for pain, chemotherapy-induced emesis and irritable bowel syndrome research.

HY-122347

Orvepitant	Antagonist
Orvepitant (GW823296) is a compound with the ability to inhibit pruritus induced by cancer epidermal growth factor receptor inhibitor (EGFRI) and is a neurokinin-1 receptor antagonist.

HY-P3854

GR 83074	Antagonist
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity.

HY-P10588

WIN 66306	Antagonist
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and NK2 receptors.

HY-117952

L 743310	Antagonist
L 743310 is a non-peptide, selective antagonist of the human neurokinin hNK1 receptor, with high affinity for primate and cloned human hNK1 receptors and lower affinity for rodent NK1 receptors. L 743310 inhibits resiniferatoxin-induced plasma protein extravasation in guinea pig esophagus. L 743310 has a dose-dependent inhibitory effect on cisplatin-induced emesis.

HY-P1193

GR 82334	Antagonist
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats.

HY-P3806

[D-Pro4,D-Trp7,9,10] Substance P (4-11)	Antagonist
[D-Pro4,D-Trp7,9,10] Substance P (4-11) is a potent tachykinin antagonist.

HY-P2439

MEN 10208	Antagonist
MEN 10208 is a neurokinin A antagonist prepared by solid phase synthesis. The Fmoc strategy has more advantages than the Boc strategy in its preparation, and can obtain products with higher yield and purity.

HY-P3803

[D-Pro4,D-Trp7,9] Substance P (4-11)	Antagonist
[D-Pro4,D-Trp7,9] Substance P (4-11) is a potent antagonist of Substance P (HY-P0201). [D-Pro4,D-Trp7,9] Substance P (4-11) decreases plasma aldosterone (ALDO) concentration.

HY-108483

RP 67580	Antagonist
RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a K_i value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation.

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