2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neurokinin Receptor
  5. Neurokinin Receptor Isoform

Neurokinin Receptor

 

Neurokinin Receptor Related Products (154):

Cat. No. Product Name Effect Purity
  • HY-10052
    Aprepitant
    		Inhibitor 99.91%
    Aprepitant (MK-0869) is a selective and high-affinity neurokinin 1 receptor antagonist with a Kd of 86 pM.
  • HY-P0187
    Senktide
    		Agonist 99.84%
    Senktide is a tachykinin NK3 receptor agonist.
  • HY-14407A
    Fosaprepitant dimeglumine
    		Antagonist 98.02%
    Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).
  • HY-16346
    Netupitant
    		Antagonist 99.93%
    Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect.
  • HY-109171
    Elinzanetant
    		Antagonist 99.82%
    Elizanetant (NT-814) is an orally active, selective NK-1,3 receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women.
  • HY-W017933
    Octahydroisoindole
    		Antagonist
    Octahydroisoindole (Perhydroisoindole) is a substance P antagonist that can cross the blood-brain barrier and is useful for the study of movement disorders associated with central nervous system diseases.
  • HY-117088
    LM11A-31
    		Modulator
    LM11A-31, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.
  • HY-P2052
    AWL 60
    		Antagonist
    AWL 60 is a compound with SP antagonist and weak opioid agonist properties, which can antagonize SP-agonists in vitro and attenuate the decrease in blood pressure caused by SP-agonists in vivo.
  • HY-P0197
    Neurokinin A
    		99.68%
    Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
  • HY-20167A
    H-Glu(OtBu)-OtBu hydrochloride
    		≥98.0%
    H-Glu(OtBu)-OtBu hydrochloride is a glutamate derivative that can be used for substance P antagonist synthesis.
  • HY-135108
    QWF Peptide
    		Antagonist 98.15%
    QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM.
  • HY-P1485A
    Substance P(1-7) TFA
    		99.02%
    Substance P(1-7) TFA is a fragment of the neuropeptide, substance P (SP). Substance P(1-7) TFA gives depressor and bradycardic effects when applied to the nucleus tractus solitarius.
  • HY-P0242A
    Neurokinin B TFA
    		Agonist 98.59%
    Neurokinin B TFA belongs to the tachykinin family of peptides. Neurokinin B binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R-to mediate their biological effect.
  • HY-P0197A
    Neurokinin A TFA
    		99.57%
    Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
  • HY-P0236A
    Neurokinin A(4-10) TFA
    		Agonist 98.84%
    Neurokinin A (4-10) TFA is a tachykinin NK2 receptor agonist.
  • HY-P99143
    Anti-Mouse NK1.1 Antibody (PK136)
    		Inhibitor
    Anti-Mouse NK1.1 Antibody is an anti-mouse NK1.1 IgG2a antibody inhibitor derived from host mouse.
  • HY-P1012
    [Sar9,Met(O2)11]-Substance P
    		Agonist 98.84%
    [Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.
  • HY-P1276A
    Men 10376 TFA
    		Antagonist 98.95%
    Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor.
  • HY-P1030
    Hemokinin 1 (mouse)
    		Agonist 99.49%
    Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively.
  • HY-P3890A
    Substance P (5-11) (TFA)
    Substance P (5-11) TFA TFA, the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) TFA TFA binds to NK-1 tachykinin receptor.