TRP Channel Inhibitor

TRP Channel Inhibitors (104):

Cat. No.	Product Name	Effect	Purity

HY-162584

TRPC4/5-IN-2	Inhibitor
TRPC4/5-IN-2 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC₅₀ value of 81 nM. TRPC4/5-IN-2 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD).

HY-170652

ZQMT-10	Inhibitor
ZQMT-10 is an orally active and potent antagonist of TRPA1, with the K_d of 1.04 μM. ZQMT-10 plays an important role in cancer research.

HY-160509

BTB 06061	Inhibitor
BTB 06061 is a TRPM7 inhibitor and can be used for study of ischemic disease.

HY-W641445

ELP-004	Inhibitor
ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca²⁺ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca²⁺ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis.

HY-30234

Clemizole	Inhibitor
Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole is an inhibitor of TRPC5 channel. The IC₅₀ of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC₅₀ for viral replication is 8 µM.

HY-144208

TRPC5-IN-3	Inhibitor
TRPC5-IN-3 is a potent TRPC5 inhibitor with IC₅₀ of 10.75 nM (WO2022001767A1, L001).

HY-149999

Xeniafaraunol A	Inhibitor
Xeniafaraunol A (compound 31) is a potent transient receptor potential melastatin 7 (TRPM7) inhibitor.

HY-144205

TRPC5-IN-2	Inhibitor
TRPC5-IN-2 is a potent TRPC5 inhibitor (WO2019055966A2, Compound IO).

HY-139006

N-Oleoyl glutamine	Inhibitor
N-oleoyl-glutamine is a PM20D1-regulated N-acyl amino acids (NAAs). N-oleoyl-glutamine is a transient receptor potential (TRP) antagonist.

HY-123245

Scalaradial	Inhibitor
Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC₅₀ of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage.

HY-N12605

hTRPA1-IN-1	Inhibitor
hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC₅₀ of 2 μM.

HY-145150

TRPC5-IN-1	Inhibitor
TRPC5-IN-1 (Compound 6j) is a selective TRPC5 inhibitor with 50.5 % Inhibition for TRPC5 at 3 μM. TRPC5-IN-1 can be used for the research of chronic kidney disease (CKD).

HY-N3230

Murpanicin	Inhibitor
Murpanicin (murraxocin) is a coumarin that is a thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel inhibitor. Murpanicin has significant anti-inflammatory and insecticidal effects.

HY-147357

TRPC3/6-IN-1	Inhibitor
TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels (TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC₅₀ values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure.

HY-108461

TRPM8-IN-1	Inhibitor
TRPM8-IN-1 (example 14) is an inhibitor of transient receptor potential melastatin-8 (TRPM8) channels, IC₅₀<5 μM.

HY-144429

TRPC5-IN-4	Inhibitor
TRPC5-IN-4 is potent and safe TRPC inhibitor with IC₅₀ value of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. TRPC5-IN-4 shows no damage on the cellular component of liver and kidney. TRPC5-IN-4 can be used for the research of chronic kidney disease (CKD).

HY-B0285BR

Amiloride hydrochloride dihydrate (Standard)	Inhibitor
Amiloride hydrochloride dihydrate (Standard) is the analytical standard of Amiloride hydrochloride dihydrate. This product is intended for research and analytical applications. Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel.

HY-W708469

Resolvin D2 methyl ester	Inhibitor
Resolvin D2 methyl ester is an ester derivative of the DHA (HY-B2167) metabolite Resolvin D2 (HY-121636) with anti-inflammatory and anti-infective activities. Resolvin D2 is a leukocyte modulator and a potent inhibitor of neuronal TRPV1 (IC₅₀=0.1 nM) and TRPA1 (IC₅₀=2 nM). Resolvin D2 can be used in sepsis research.

HY-125527AS

17(R)-Resolvin D1-d₅	Inhibitor
17(R)-Resolvin D1-d₅ (17(R)-RvD1-d₅) is deuterium labeled 17(R)-Resolvin D1. 17R-Resolvin D1 (17R-RvD1; AT-RvD1) is an aspirin-triggered epimer of Resolvin D1, which exhibits anti-inflammatory activity in mice and human PMNs cells. 17R-Resolvin D1 specificially inhibits TRPV3 with an IC₅₀ of 398 nM and exhibits peripheral anti-nociceptive efficacy.

HY-157574

TRPV6-IN-1	Inhibitor
TRPV6-IN-1 is a potent and selective TRPV6 inhibitor. TRPV6-IN-1 has anti-proliferative effect and can be used for the research of cancer.

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