TRP Channel

Channel

Transient receptor potential channels

TRP Channel

TRP Channel Isoform Specific Products:

TRP Channel Related Products (393)
Antibodies (3)
TRP Channel Isoform Comparison

By Effects:	Controls (3) Ligand (1) Inhibitors (109) Agonists (91) Antagonists (96) Activators (55) Modulators (17)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-17386

Rosiglitazone	Modulator	99.94%
Rosiglitazone (BRL 49653) is an orally active selective PPARγ agonist (EC₅₀: 60 nM, K_d: 40 nM). Rosiglitazone is an TRPC5 activator (EC₅₀: 30 μM) and TRPM3 inhibitor. Rosiglitazone can be used in the research of obesity and diabetes, senescence, ovarian cancer.

HY-P1410

GsMTx4	Inhibitor	99.80%
GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.

HY-10448

Capsaicin	Agonist	99.88%
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects.

HY-101840

EIPA	Inhibitor	99.73%
EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC₅₀ of 10.5 μM. EIPA also enhances autophagy by inhibiting Na⁺/H⁺-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.

HY-B0545

Probenecid	Agonist	99.92%
Probenecid is a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Probenecid also inhibits pannexin 1 channels.

HY-N0172R

Caffeic acid (Standard)	Inhibitor
Caffeic acid (Standard) is the analytical standard of Caffeic acid. This product is intended for research and analytical applications. Caffeic acid is an inhibitor of both TRPV1 ion channel and 5-Lipoxygenase (5-LO).

HY-W014325R

TRPM8 agonist WS-3 (Standard)	Agonist
TRPM8 agonist WS-3 (Standard) is the analytical standard of TRPM8 agonist WS-3. This product is intended for research and analytical applications. TRPM8 agonist WS-3 is an agonist of TRPM8 with an EC50 of 3.7 μM.

HY-W009724

2-Aminoethyl diphenylborinate	Activator	99.86%
2-Aminoethyl diphenylborinate (2-APB) is a cell-permeable inhibitor of Inositol triphosphate receptor (IP3R). 2-Aminoethyl diphenylborinate also inhibits the store-operated Ca²⁺ (SOC) channel and activates some TRP channels (V1, V2 and V3). Additionally, 2-Aminoethyl diphenylborinate has inhibitory effects on vasospasm. At high concentrations, it exhibits specific anti-inflammatory and antioxidant effects in neural tissue.

HY-100965

Diphenyleneiodonium chloride	Activator	99.91%
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-19608

GSK1016790A	Agonist	99.79%
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca²⁺ influx and elevate intracellular Ca²⁺ in HEK cells.

HY-15640

Capsazepine	Antagonist	≥99.0%
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC₅₀ of 562 nM.

HY-N2333

Resiniferatoxin	Agonist	99.77%
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period.

HY-B0285

Amiloride	Inhibitor	99.96%
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride is a blocker of polycystin-2 (PC2; TRPP2) channel.

HY-100208

HC-067047	Antagonist	99.89%
HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC₅₀ values of 48 nM, 133 nM, and 17 nM, respectively.

HY-B0285A

Amiloride hydrochloride	Inhibitor	99.83%
Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2) channel.

HY-152182

ML-SA5	Agonist	99.57%
ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC₅₀ of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth.

HY-P1410A

GsMTx4 TFA	Inhibitor	99.80%
GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology.

HY-108462

ML-SA1	Agonist	99.44%
ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC₅₀ value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral.

HY-15064

HC-030031	Inhibitor	99.49%
HC-030031 is a potent and selective TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC₅₀s of 6.2±0.2 and 5.3±0.2 μM, respectively.

HY-100720

GSK2193874	Antagonist	99.91%
GSK2193874 is an orally active, potent, and selective TRPV4 antagonist with IC₅₀s of 2 nM and 40 nM for rTRPV4 and hTRPV4.

Rosiglitazone	TRPC5, EC₅₀: 30 μM					99.94%
GSK1016790A			TRPV4			99.79%
Anandamide			TRPV1			≥99.0%
SB-366791			hTRPV1, IC₅₀: 5.7 nM			98.11%
ML-SI3					TRPML1, IC₅₀: 4.7 μM	99.91%
CIM0216		TRPM3				99.94%
Icilin		TRPM8				99.26%
Dihydrocapsaicin			TRPV1			99.93%
JNJ-28583113		TRPM2				98.82%
(1R,2R)-ML-SI3					TRPML1, IC₅₀: 1.6 μM TRPML2, IC₅₀: 2.3 μM TRPML3, IC₅₀: 12.5 μM	99.79%
GSK1702934A	TRPC3					99.11%
SET2			TRPV2, IC₅₀: 0.46 μM			99.78%
LE135			TRPV1, EC₅₀: 2.5 μM	TRPA1, EC₅₀: 20 μM		≥99.0%
ML204	TRPC4 TRPC5					99.08%
Englerin A	hTRPC4, EC₅₀: 11.2 nM hTRPC5, EC₅₀: 7.6 nM					99.50%
Pyr10	TRPC3, IC₅₀: 0.72 μM					99.95%
(rel)-ML-SI3					TRPML1, IC₅₀: 3.1 μM TRPML2, EC₅₀: 3.3 μM TRPML3, IC₅₀: 28.5 μM	99.81%
Acoltremon		TRPM8				99.90%
Rosiglitazone hydrochloride	TRPC5, EC₅₀: 30 μM					99.81%
9-Phenanthrol		TRPM4, IC₅₀: 17 μM				99.61%
TRPV2-selective blocker 1			TRPV2, IC₅₀: 6.3 μM			99.84%
SOR-C13 TFA			TRPV6, IC₅₀: 14 nM			99.18%
RQ-00203078		TRPM8, IC₅₀: 5.3 nM (Rat TRPM8 channels) TRPM8, IC₅₀: 8.3 nM (Human TRPM8 channels)	TRPV4, IC₅₀: 10 μM			99.84%
Larixyl acetate	hTRPC6, IC₅₀: 0.58 μM hTRPC3, IC₅₀: 6.83 μM					99.46%
TRPV3 antagonist 74a			TRPV3			99.85%
AP-18				TRPA1, IC₅₀: ~3 μM		99.61%
PF-04745637				TRPA1, IC₅₀: 17 nM		99.97%
Ononetin		TRPM3, IC₅₀: 0.3 μM				99.54%
Capsiate			TRPV1			99.85%
JNJ-17203212			TRPV1			99.94%
ML204 hydrochloride	TRPC4 TRPC5					99.74%
TRPV1 antagonist 3		TRPM8, IC₅₀: 7.45 μM	hTRPV1, IC₅₀: 2.66 nM			99.30%
Phenamil methanesulfonate	TRPC3, IC₅₀: 140 nM					98.1%
M8-B		TRPM8				99.89%
(1S,2S)-ML-SI3					TRPML1, IC₅₀: 5.9 μM TRPML2, EC₅₀: 2.7 μM TRPML3, EC₅₀: 10.8 μM	99.82%
Olvanil			TRPV1, EC₅₀: 0.7 nM			≥99.0%
AS1269574				TRPA1		99.84%
SOR-C13 acetate			TRPV6, IC₅₀: 14 nM			98.56%
Chrysin 6-C-glucoside 8-C-arabinoside			TRPV1			99.11%
MDR-652			hTRPV1, Ki: 11.4 nM rTRPV1, Ki: 23.8 nM hTRPV1, EC₅₀: 5.05 nM rTRPV1, EC₅₀: 93 nM			99.02%
SOR-C13			TRPV6, IC₅₀: 14 nM			98.56%
MSP-3			TRPV1, EC₅₀: 0.87 μM			98.53%
TRPA1-IN-2				TRPA1, IC₅₀: 0.04 μM		99.82%
JW-65	TRPC3					99.05%
Chembridge-5861528				TRPA1, IC₅₀: 14.3 μM (allyl isothiocyanate-evoked TRPA1 response) TRPA1, IC₅₀: 18.7 μM (4-HNE-evoked TRPA1 response)		99.76%
Vanillyl butyl ether		TRPM8	TRPV1			99.67%
(R)-Methanandamide			TRPV1
Libvatrep			TRPV1			99.54%
RN-1665			hTRPV4, IC₅₀: 0.26 μM rTRPV4, IC₅₀: 0.39 μM			99.93%
N-Arachidonoyl Taurine			TRPV1, EC₅₀: 28 μM TRPV4, Ki: 21 μM			≥99.0%
Artepillin C				TRPA1, : 1.8 μM
GFB-8438	hTRPC5, IC₅₀: 0.18 μM hTRPC4, IC₅₀: 0.29 μM rTRPC5, IC₅₀: 0.18 μM					99.74%
17(R)-Resolvin D1			TRPV3, IC₅₀: 398 nM			99.1%
D-erythro-Sphingosine hydrochloride		TRPM3
Dihydrocapsiate			TRPV1			99.18%
ABT-102			TRPV1
N-Arachidonyldopamine			TRPV1, EC₅₀: ~50 nM			98.36%
Rosiglitazone potassium	TRPC5, EC₅₀: 30 μM
V116517			TRPV1
CBP-1008			TRPV6
FAAH/TRPV1 blocker-1			TRPV1, IC₅₀: 94.9 μM
Methyl kakuol				TRPA1
Polygodial pyridazine			TRPV1
AAL-149		TRPM7, IC₅₀: 1.081 μM
TRPM7-IN-1		TRPM7
TRPV4 antagonist 4			TRPV4, IC₅₀: 22.65 nM
JTS-653			TRPV1
TRPC antagonist 1	TRPC3, IC₅₀: 2.4 μM TRPC4, IC₅₀: 12.2 μM TRPC5, IC₅₀: 7.6 μM TRPC6, IC₅₀: 2.9 μM TRPC7, IC₅₀: 3.4 μM
TRPV4-IN-5			TRPV4, IC₅₀: 0.46 μM
TRPV1-IN-2				TRPA1
L-R4W2 TFA			TRPV1, IC₅₀: 0.1 μM
CMP233		TRPM4, IC₅₀: 0.15 μM
TRPC5-IN-5	TRPC5, IC₅₀: 1.28 μM
L687	TRPC3 TRPC6 TRPC7
TRPC4/5-IN-1	TRPC5, IC₅₀: 0.54 μM TRPC4, IC₅₀: 2.06 μM
TRPC4/5-IN-2	TRPC5
TRPC4/5-IN-3	TRPC4, IC₅₀: 3.6 nM TRPC5, IC₅₀: 5.5 nM
L-R4W2			TRPV1, IC₅₀: 0.1 μM
Artepillin C (Standard)				TRPA1, : 1.8 μM
ZQMT-10				TRPA1, Ki: 1.04 μM
TRPV1 antagonist 10		TRPM8, IC₅₀: 6.47 μM	TRPV1, IC₅₀: 36.47 nM TRPV3, IC₅₀: >100 μM TRPV4, IC₅₀: >100 μM	TRPA1, IC₅₀: >100 μM
MK-2295			TRPV1
GDC-0334				TRPA1
Xeniafaraunol A		TRPM7
TRPV1/CB2 agonist 1			TRPV1, EC₅₀: 26.8 μM
TRPV1 antagonist 5			TRPV1
AMG8788				TRPA1, IC₅₀: 1 μM
AMG9678				TRPA1, IC₅₀: 0.6 μM
TRPV1 antagonist 11			TRPV1, IC₅₀: 29.3 nM
TRPM8-IN-1		TRPM8, IC₅₀: <5 μM
TRPC5-IN-4	TRPC5, IC₅₀: 14.07 nM TRPC4, IC₅₀: 65 nM
Protokylol hydrochloride			TRPV1
TRPV6-IN-1			TRPV6
TRPC3/6-IN-1	hTRPC3, IC₅₀: 1260 nM hTRPC6, IC₅₀: 500 nM
TRPA1-IN-3				TRPA1

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TRP Channel

TRP Channel

TRP Channel Isoform Specific Products:

TRP Channel Isoform Specific Products:

TRP Channel Related Products (393)

Antibodies (3)

TRP Channel Isoform Comparison

TRP Channel Related Products (393):