2. Signaling Pathways
  3. Anti-infection
  4. Beta-lactamase

Beta-lactamase

β-lactamase

Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.

Beta-lactamase Isoform Specific Products:

Beta-lactamase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1354
    Cefpiramide
    		Inhibitor
    Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase.
    Cefpiramide
  • HY-B0479R
    Thiamphenicol (Standard)
    		Inhibitor
    Thiamphenicol (Standard) is the analytical standard of Thiamphenicol. This product is intended for research and analytical applications. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria).
    Thiamphenicol (Standard)
  • HY-160255A
    N-Cbz-D-Cysteine
    		Inhibitor
    N-Cbz-D-Cysteine (Cbz-D-Cys) (compound 5) is a potent β-lactamase II inhibitor with a Ki value of 20.1 µM.
    N-Cbz-D-Cysteine
  • HY-A0256R
    Clavulanic acid (Standard)
    		Inhibitor
    Clavulanic acid (Standard)
  • HY-160255
    N-Cbz-L-Cysteine
    		Inhibitor
    N-Cbz-L-Cysteine (Cbz-cysteine) (compound 5) is a potent β-lactamase II inhibitor with a Ki value of 97 µM.
    N-Cbz-L-Cysteine
  • HY-144659
    Metallo-β-lactamase-IN-5
    		Inhibitor
    Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity.
    Metallo-β-lactamase-IN-5
  • HY-A0088AR
    Cefotaxime (Standard)
    		Inhibitor
    Cefotaxime (Standard) is the analytical standard of Cefotaxime. This product is intended for research and analytical applications. Cefotaxime, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
    Cefotaxime (Standard)
  • HY-146165
    Metallo-β-lactamase-IN-8
    		Inhibitor
    Metallo-β-lactamase-IN-8 (compound 17) is a potent, reversible and competitive broad-spectrum inhibitor of metallo-β-lactamases (MβLs), with IC50s of 1.3 μM, 5.7 μM, 9.8 μM, and 9.9 μM for L1, ImiS, IMP-1 and VIM-2, respectively. Metallo-β-lactamase-IN-8 exhibits antibacterial activity.
    Metallo-β-lactamase-IN-8
  • HY-139744
    FPI-1465
    		Inhibitor
    FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively.
    FPI-1465
  • HY-19050
    BRL-42715
    		Inhibitor
    BRL-42715 is a potent inhibitor of a broad range of bacterial beta-lactamases (β-lactamase) .
    BRL-42715
  • HY-143415
    Metallo-β-lactamase-IN-7
    		Inhibitor
    Metallo-β-lactamase-IN-7 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.019 μM, 13.64 μM, 0.38 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-7 potentiate antibacterial activity of Meropenem against the Gram-negative bacterial strains.
    Metallo-β-lactamase-IN-7
  • HY-144262
    Metallo-β-lactamase-IN-4
    		Inhibitor
    Metallo-β-lactamase-IN-4 (compound 40) is a potent metallo-β-lactamases (MBL) inhibitor, with IC50 values of 0.5 μM (VIM-1), 2.1 μM (NDM-1), and 3.3 μM (IMP-7), respectively.
    Metallo-β-lactamase-IN-4
  • HY-B1484A
    Moxalactam
    		Inhibitor
    Moxalactam (Latamoxef) is a synthetic oxa-β-lactam antibiotic. Moxalactam has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam inhibits production of β-lactamases.
    Moxalactam
  • HY-119945A
    Brobactam sodium
    		Inhibitor
    Brobactam sodium is a potent synthetic wide spectrum β-lactamase inhibitor. Brobactam sodium has antibacterial activity.
    Brobactam sodium
  • HY-155283
    Zndm19
    		Inhibitor
    Zndm19 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor. Zndm19 can be used for the research of drug-resistant bacterial infections.
    Zndm19
  • HY-146637
    VIM-2-IN-1
    		Inhibitor
    VIM-2-IN-1 (compound 1dj) is a β-lactamase inhibitor with antibacterial activities. VIM-2-IN-1 has moderate IC50 values of 23 µM, 48 µM and 231 µM for Verona integron-encoded metallo-β-lactamase (VIM-2), German imipenemase-1 (GIM-1) and New Delhi metallo-β-lactamase (NDM-1), respectively.
    VIM-2-IN-1
  • HY-139751
    β-Lactamase-IN-4
    		Inhibitor
    β-Lactamase-IN-4 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 708. β-Lactamase-IN-4 can be used for the research of bacterial infections.
    β-Lactamase-IN-4
  • HY-143414
    Metallo-β-lactamase-IN-6
    		Inhibitor
    Metallo-β-lactamase-IN-6 is a potent VIM-Type metallo-β-lactamase inhibitor with IC50s of 0.56 μM, 29.50 μM and 5.78 μM for VIM-2, VIM-1 and VIM-5. Metallo-β-lactamase-IN-6 displays potent synergistic antibacterial activity with Meropenem against engineered Escherichia coli strains and intractable clinically isolated Pseudomonas aeruginosa producing VIM-2 MBL.
    Metallo-β-lactamase-IN-6
  • HY-139746
    FPI-1602
    		Inhibitor
    FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp..
    FPI-1602
  • HY-158375
    MBL-IN-4
    		Inhibitor
    MBL-IN-4 (compound 4b) is a MBL inhibitor with the IC50 of 4.81 and 33 μM against IMP-1 and NDM-1.
    MBL-IN-4
Beta-lactamase Isoform Comparison

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