2. Anti-infection
  3. Beta-lactamase Antibiotic Bacterial
  4. Cefpiramide

Cefpiramide  (Synonyms: SM-1652 free acid; Wy-44635 free acid)

Cat. No.: HY-B1354 Purity: 99.27%
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Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase.

For research use only. We do not sell to patients.

Cefpiramide Chemical Structure

Cefpiramide Chemical Structure

CAS No. : 70797-11-4

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Based on 1 publication(s) in Google Scholar

Other Forms of Cefpiramide:

Cefpiramide Related Antibodies

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  • Biological Activity

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Description

Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase[1][2].

IC50 & Target

β-lactam

 

In Vitro

Cefpiramide (0-2048 µg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 µg/mL with 97% inhibition)[1].
Cefpiramide (0-2048 µg/mL; 16-18 hours) exhibits high effective to against Pseudomonas aeruginosa with MIC[50] and MIC[90] values of 4 µg/mL and 16 µg/mL separately[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefpiramide Related Antibodies

Cell Viability Assay[1]

Cell Line: 761 bacterial isolates (35 different species of common bacterial pathogens)
Concentration: 0-2048 µg/mL
Incubation Time: 16-18 hours
Result: Showed broad-spectrum antibacterial activity.
In Vivo

Cefpiramide (25 mg/kg; i.v.; once) shows anti-Streptococcus pneumoniae activity in experimental pneumococcal meningitis[2].
Cefpiramide (25 mg/kg; i.v.; once) reduces bacteria in CSF more than 10[4] CFU/ml[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand white male rabbits(2-3 kg)[2].
Dosage: 25 mg/kg
Administration: Intravenous injection; once.
Result: Anti-Streptococcus pneumoniae.
Molecular Weight

612.64

Formula

C25H24N8O7S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@H](NC([C@H](NC(C4=C(O)C=C(C)N=C4)=O)C5=CC=C(O)C=C5)=O)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (204.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6323 mL 8.1614 mL 16.3228 mL
5 mM 0.3265 mL 1.6323 mL 3.2646 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6323 mL 8.1614 mL 16.3228 mL 40.8070 mL
5 mM 0.3265 mL 1.6323 mL 3.2646 mL 8.1614 mL
10 mM 0.1632 mL 0.8161 mL 1.6323 mL 4.0807 mL
15 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7205 mL
20 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
25 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
30 mM 0.0544 mL 0.2720 mL 0.5441 mL 1.3602 mL
40 mM 0.0408 mL 0.2040 mL 0.4081 mL 1.0202 mL
50 mM 0.0326 mL 0.1632 mL 0.3265 mL 0.8161 mL
60 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6801 mL
80 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5101 mL
100 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4081 mL
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Cefpiramide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefpiramide70797-11-4SM-1652Wy-44635SM1652SM 1652Wy44635Wy 44635Beta-lactamaseAntibioticBacterialβ-lactamasebroad-spectrum antibacterialInhibitorinhibitorinhibit

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