c-Fms

CSF-1 receptor; colony stimulating factor 1 receptor; CSF-1R; CSF1R

c-Fms

Related Products

c-FMS (CSF1R, CSF-1R) is a receptor protein-tyrosine kinase of the platelet-derived growth factor receptor (PDGFR) family. c-FMS is the cell surface receptor for IL-34 and CSF1. c-FMS has important roles in haematopoiesis, regulation of proliferation, cell survival and maturation of microglia and monocytes, as well as in controlling the overall immune response.

c-FMS is specifically expressed in osteoclasts and myelomonocytic-lineage cells, such as monocytes and macrophages, and the activation of c-FMS signaling promotes the proliferation or differentiation of these cells. It also promotes the production of inflammatory mediators, such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL6).

c-Fms Related Products (112)
Recombinant Proteins (21)
Antibodies (9)

By Effects:	Inhibitors (97) Antagonist (1) Chemical (1) Inducers (3)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P99307

Namilumab	Inhibitor	99.47%
Namilumab (AMG203) is a human IgG1 monoclonal antibody that binds with high affinity to the GM-CSF ligand, potently neutralizing GM-CSF. Namilumab can be used for the research of rheumatoid arthritis.

HY-P990094

Trabikibart		99.17%
Trabikibart (CSL311), a βc (CSF2RB)-specific, fully human monoclonal antibody, binds to a unique epitope that is specific to the cytokine-binding site of the human βc receptor. Trabikibart has picomolar binding affinity for the human βc receptor. Trabikibart is a potent inhibitor of the combined effects of IL-3, GM-CSF and IL-5 on the survival of eosinophils. Trabikibart has the potential for chronic inflammatory diseases research.

HY-112451

cFMS Receptor Inhibitor II	Inhibitor	99.88%
cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor. CSF-1 is a cytokine.

HY-P990125

Anti-Mouse (CSF1R/CD115) Antibody (AFS98)		99.38%
Anti-Mouse CSF1R (CD115) Antibody (AFS98) is a rat-derived IgG2a, κ type antibody inhibitor, targeting to mouse CSF1R.

HY-159108

AZ683	Inhibitor	98.57%
AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (K_i=8 nM; IC₅₀=6 nM). AZ683 has good oral bioavailability. [¹¹C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R).

HY-119942

c-Fms-IN-8	Inhibitor	99.47%
c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC₅₀ of 9.1 nM.

HY-152830A

Adrixetinib TFA	Inhibitor	99.82%
Adrixetinib (Q702) TFA is a selective Axl/Mer/CSF1R protein tyrosine kinase inhibitor with antineoplastic activity.

HY-18787

c-Fms-IN-2	Inhibitor	99.79%
c-Fms-IN-2 is a FMS kinase inhibitor with an IC₅₀ of 0.024 μM.

HY-101526

GENZ-882706	Inhibitor
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1.

HY-160842

CSF1R-IN-24	Inhibitor	98.10%
CSF1R-IN-24 (Example 134) is an orally active CSF1R inhibitor. CSF1R-IN-24 significantly inhibits the survival of human ipSC-derived microglia (hiPSC-MG).

HY-101526R

GENZ-882706(Raceme)	Inhibitor	98.79%
GENZ-882706(Raceme) is the racemate of GENZ-882706. GENZ-882706(Raceme) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-12009S

Pazopanib-¹³C,d₃ hydrochloride
Pazopanib-¹³C,d₃ (hydrochloride) is the deuterium and ¹³C labeled Pazopanib hydrochloride[1]. Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1/Flt-1, VEGFR2/KDR/Flk-1, VEGFR3/Flt-4, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively[2][3].

HY-132935A

BPR1R024 mesylate	Inhibitor
BPR1R024 mesylate is an orally active and selective colony-stimulating factor-1 receptor (CSF1R) inhibitor. BPR1R024 mesylate is the equivalent of BPR1R024 (HY-132935). BPR1R024 has potent CSF1R inhibition activity with an IC₅₀ value of 0.53 nM. BPR1R024 can be used for the research of immuno-oncology.

HY-148181

c-Fms-IN-13	Inhibitor	99.27%
c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor with an IC₅₀ value of 17 nM. c-Fms-IN-13 can be used as an anti-inflammatory agent.

HY-10917S

GW2580-d₆	Inhibitor	98.36%
GW2580-d6 is the deuterium labeled GW2580. GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling.

HY-13075

c-Fms-IN-3	Inhibitor	99.69%
c-Fms-IN-3 is a novel c-Fms kinase inhibitor with a potential as anti-inflammatory agent and antirheumatic agent.

HY-P99368

Lacnotuzumab	Inhibitor
Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting CSF-1 that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis.

HY-152830

Adrixetinib	Inhibitor	99.51%
Adrixetinib (Q702) is an Axl/Mer/CSF1R protein tyrosine kinase inhibitor with antineoplastic activity.

HY-12768B

Sotuletinib dihydrochloride	Inhibitor
Sotuletinib (BLZ945) dihydrochloride is an orally active and blood-brain barrier-permeable CSF1-R-specific inhibitor (IC₅₀=1 nM). Sotuletinib (BLZ945) dihydrochloride induces tumor cell apoptosis and effectively inhibits tumor growth in mouse models. Sotuletinib dihydrochloride can be used in cancer and amyotrophic lateral sclerosis (ALS) research.

HY-P99134

Anti-Mouse GM-CSF Antibody (MP1-22E9)	Inhibitor
Anti-Mouse GM-CSF Antibody is an anti-mouse GM-CSF IgG2a antibody inhibitor derived from host Rat.

Name
Email *

	Sorry, but the email address you supplied was invalid.

c-Fms

c-Fms

c-Fms Related Products (112)

Recombinant Proteins (21)

Antibodies (9)

c-Fms Related Products (112):