2. Protein Tyrosine Kinase/RTK
  3. c-Fms TAM Receptor
  4. Adrixetinib

Adrixetinib (Q702) is an Axl/Mer/CSF1R protein tyrosine kinase inhibitor with antineoplastic activity.

For research use only. We do not sell to patients.

Adrixetinib Chemical Structure

Adrixetinib Chemical Structure

CAS No. : 2394874-66-7

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5 mg USD 679 In-stock
10 mg USD 1087 In-stock
25 mg USD 2175 In-stock
50 mg USD 3480 In-stock
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Based on 1 publication(s) in Google Scholar

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Axl Mer Tyro3

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Description

Adrixetinib (Q702) is an Axl/Mer/CSF1R protein tyrosine kinase inhibitor with antineoplastic activity[1][2].

Molecular Weight

531.48

Formula

C25H24F3N5O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NN(CCC)C=C1OCC(F)(F)F)NC2=NC=C(C=C2)OC3=C4C=C(OC)C(OC)=CC4=NC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (188.15 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8815 mL 9.4077 mL 18.8154 mL
5 mM 0.3763 mL 1.8815 mL 3.7631 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8815 mL 9.4077 mL 18.8154 mL 47.0385 mL
5 mM 0.3763 mL 1.8815 mL 3.7631 mL 9.4077 mL
10 mM 0.1882 mL 0.9408 mL 1.8815 mL 4.7038 mL
15 mM 0.1254 mL 0.6272 mL 1.2544 mL 3.1359 mL
20 mM 0.0941 mL 0.4704 mL 0.9408 mL 2.3519 mL
25 mM 0.0753 mL 0.3763 mL 0.7526 mL 1.8815 mL
30 mM 0.0627 mL 0.3136 mL 0.6272 mL 1.5679 mL
40 mM 0.0470 mL 0.2352 mL 0.4704 mL 1.1760 mL
50 mM 0.0376 mL 0.1882 mL 0.3763 mL 0.9408 mL
60 mM 0.0314 mL 0.1568 mL 0.3136 mL 0.7840 mL
80 mM 0.0235 mL 0.1176 mL 0.2352 mL 0.5880 mL
100 mM 0.0188 mL 0.0941 mL 0.1882 mL 0.4704 mL
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Adrixetinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adrixetinib2394874-66-7Q702Q 702Q-702c-FmsTAM ReceptorCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RTyro3AxlMerInhibitorinhibitorinhibit

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