2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. c-Fms-IN-13

c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor with an IC50 value of 17 nM. c-Fms-IN-13 can be used as an anti-inflammatory agent.

For research use only. We do not sell to patients.

c-Fms-IN-13 Chemical Structure

c-Fms-IN-13 Chemical Structure

CAS No. : 885704-58-5

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Based on 1 publication(s) in Google Scholar

c-Fms-IN-13 Related Antibodies

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Description

c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor with an IC50 value of 17 nM. c-Fms-IN-13 can be used as an anti-inflammatory agent[1].

IC50 & Target

IC50: 17 nM (FMS)[1]
Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
0.017 μM
Compound: 14
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization
Inhibition of human cytoplasmic FMS expressed in Sf9-baculovirus system after 80 mins by fluorescence polarization
[PMID: 18242992]
Molecular Weight

378.47

Formula

C22H26N4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=CC=C(C(NC2=CC=C(N3CCCCC3)C=C2N4CCCCC4)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 31.25 mg/mL (82.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6422 mL 13.2111 mL 26.4222 mL
5 mM 0.5284 mL 2.6422 mL 5.2844 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6422 mL 13.2111 mL 26.4222 mL 66.0554 mL
5 mM 0.5284 mL 2.6422 mL 5.2844 mL 13.2111 mL
10 mM 0.2642 mL 1.3211 mL 2.6422 mL 6.6055 mL
15 mM 0.1761 mL 0.8807 mL 1.7615 mL 4.4037 mL
20 mM 0.1321 mL 0.6606 mL 1.3211 mL 3.3028 mL
25 mM 0.1057 mL 0.5284 mL 1.0569 mL 2.6422 mL
30 mM 0.0881 mL 0.4404 mL 0.8807 mL 2.2018 mL
40 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6514 mL
50 mM 0.0528 mL 0.2642 mL 0.5284 mL 1.3211 mL
60 mM 0.0440 mL 0.2202 mL 0.4404 mL 1.1009 mL
80 mM 0.0330 mL 0.1651 mL 0.3303 mL 0.8257 mL
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c-Fms-IN-13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

c-Fms-IN-13885704-58-5c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Ranti-inflammatoryInhibitorinhibitorinhibit

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