2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. AZ683

AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R).

For research use only. We do not sell to patients.

AZ683 Chemical Structure

AZ683 Chemical Structure

CAS No. : 953798-95-3

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Based on 1 publication(s) in Google Scholar

AZ683 Related Antibodies

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Description

AZ683 is a potent and selective 3-amido-4-anilinoquinoline CSF1R inhibitor. AZ683 has high affinity for CSF1R (Ki=8 nM; IC50=6 nM). AZ683 has good oral bioavailability. [11C]AZ683 can be used as a positron emission tomography (PET) radiotracer for colony stimulating factor 1 receptor (CSF1R)[1][2].

IC50 & Target

IC50: 6 nM (CSF1R)[1]
In Vitro

AZ683 has an IC50 of 3.5 μM in a canine cardiac myocyte L-type Ca channel current assay, and also inhibits the human cardiac NaV1.5 channel (IC50 14 μM)[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZ683 Related Antibodies
Molecular Weight

441.47

Formula

C23H25F2N5O2
CAS No.
SMILES

O=C(C1=CN=C2C=C(C(N3CCN(CC3)C)=CC2=C1NC4=CC=C(C=C4F)F)OCC)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZ683 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ683953798-95-3AZ 683AZ-683c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1Rcardiovascular liabilitiescardiac myocyteoral bioavailabilityInhibitorinhibitorinhibit

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