Adrixetinib TFA (Synonyms: Q702 TFA)

Cat. No.: HY-152830A Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

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Adrixetinib (Q702) TFA is a selective Axl/Mer/CSF1R protein tyrosine kinase inhibitor with antineoplastic activity.

For research use only. We do not sell to patients.

Adrixetinib TFA Chemical Structure

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 964	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 964	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 679	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1087	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 2175	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3480	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Adrixetinib (Q702) TFA is a selective Axl/Mer/CSF1R protein tyrosine kinase inhibitor with antineoplastic activity^[1]^[2]^[3].

Molecular Weight

645.51

Formula

C₂₇H₂₅F₆N₅O₇

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=NN(CCC)C=C1OCC(F)(F)F)NC2=NC=C(C=C2)OC3=C4C=C(OC)C(OC)=CC4=NC=C3.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (154.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5492 mL	7.7458 mL	15.4916 mL
5 mM	0.3098 mL	1.5492 mL	3.0983 mL
10 mM	0.1549 mL	0.7746 mL	1.5492 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (247 KB) HNMR (259 KB) RP-HPLC (248 KB) LCMS (117 KB)

Handling Instructions (2659 KB)

References

[1]. WHO Drug Informat ion - World Health Organization (WHO).

[2]. Nam Kiyean, et al. Quinoline derivatives as inhibitors of Axl/Mer RTK and CSF1R and their preparation: World Intellectual Property Organization, WO2019229251. 2019-12-05.

[3]. WHO Drug Information-World Health Organization (WHO).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5492 mL	7.7458 mL	15.4916 mL	38.7291 mL
	5 mM	0.3098 mL	1.5492 mL	3.0983 mL	7.7458 mL
	10 mM	0.1549 mL	0.7746 mL	1.5492 mL	3.8729 mL
	15 mM	0.1033 mL	0.5164 mL	1.0328 mL	2.5819 mL
	20 mM	0.0775 mL	0.3873 mL	0.7746 mL	1.9365 mL
	25 mM	0.0620 mL	0.3098 mL	0.6197 mL	1.5492 mL
	30 mM	0.0516 mL	0.2582 mL	0.5164 mL	1.2910 mL
	40 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.9682 mL
	50 mM	0.0310 mL	0.1549 mL	0.3098 mL	0.7746 mL
	60 mM	0.0258 mL	0.1291 mL	0.2582 mL	0.6455 mL
	80 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.4841 mL
	100 mM	0.0155 mL	0.0775 mL	0.1549 mL	0.3873 mL

Adrixetinib TFA Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Adrixetinib TFA (Synonyms: Q702 TFA)

Customer Review

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Complete Stock Solution Preparation Table

Adrixetinib TFA Related Classifications

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