2. Others Protein Tyrosine Kinase/RTK
  3. Isotope-Labeled Compounds c-Fms
  4. GW2580-d6

GW2580-d6 is the deuterium labeled GW2580. GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling.

For research use only. We do not sell to patients.

GW2580-d<sub>6</sub> Chemical Structure

GW2580-d6 Chemical Structure

CAS No. : 2733770-48-2

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1 mg USD 970 In-stock
5 mg USD 2115 In-stock
10 mg USD 3515 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of GW2580-d6:

GW2580-d6 Related Antibodies

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Description

GW2580-d6 is the deuterium labeled GW2580. GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GW2580-d6 Related Antibodies
Molecular Weight

372.45

Formula

C20H16D6N4O3
CAS No.
Unlabeled CAS

870483-87-7
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(N)=C(CC2=CC(OC([2H])([2H])[2H])=C(OCC3=CC=C(OC([2H])([2H])[2H])C=C3)C=C2)C=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (268.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6849 mL 13.4246 mL 26.8492 mL
5 mM 0.5370 mL 2.6849 mL 5.3698 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6849 mL 13.4246 mL 26.8492 mL 67.1231 mL
5 mM 0.5370 mL 2.6849 mL 5.3698 mL 13.4246 mL
10 mM 0.2685 mL 1.3425 mL 2.6849 mL 6.7123 mL
15 mM 0.1790 mL 0.8950 mL 1.7899 mL 4.4749 mL
20 mM 0.1342 mL 0.6712 mL 1.3425 mL 3.3562 mL
25 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6849 mL
30 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2374 mL
40 mM 0.0671 mL 0.3356 mL 0.6712 mL 1.6781 mL
50 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3425 mL
60 mM 0.0447 mL 0.2237 mL 0.4475 mL 1.1187 mL
80 mM 0.0336 mL 0.1678 mL 0.3356 mL 0.8390 mL
100 mM 0.0268 mL 0.1342 mL 0.2685 mL 0.6712 mL
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GW2580-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW2580-d62733770-48-2Isotope-Labeled Compoundsc-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RInhibitorinhibitorinhibit

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