Apocynin-d₃  (Synonyms: Acetovanillone-d₃)

Apocynin-d₃ is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

169.19

C₉H₇D₃O₃

80404-23-5

498-02-2

[2H]C([2H])([2H])OC1=CC(C(C)=O)=CC=C1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Stolk J,et al. Am J Respir Cell Mol Biol, 1994, 11(1), 95-102.  [Content Brief]

  [3]. Stefanska J, et al. Mediators Inflamm, 2008, 106507.  [Content Brief]

  [4]. Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 181(5):636-48.  [Content Brief]