2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. BChE-IN-11

BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

BChE-IN-11 Chemical Structure

BChE-IN-11 Chemical Structure

CAS No. : 133740-30-4

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BChE-IN-11 Related Antibodies

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Description

BChE-IN-11 (compound 10) is a potent, selective and non-competitive BChE (butyrylcholinesterase) inhibitor, with an IC50 of 2.1 μM. BChE-IN-11 can be used for Alzheimer's disease (AD) research[1].

IC50 & Target

BChE

2.1 ± 0.3 μM (IC50)

AChE

 

In Vitro

BChE-IN-11 (compound 10) shows inhibition activity for BChE and AChE, with inhibition of 96.6 ± 1.2% and 19.1 ± 3.8% at 25 μg/mL, respectively[1]. BChE-IN-11 binds to the active pocket of BChE via multiple hydrogen bonds with His438, Pro285, Gly115 and π–π stacking with Tyr332 and Trp82[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BChE-IN-11 Related Antibodies
Molecular Weight

346.38

Formula

C22H18O4
CAS No.
SMILES

OC1=CC(OC)=C2C3=CC=C(O)C=C3C=CC2=C1CC4=CC=C(O)C=C4
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BChE-IN-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BChE-IN-11133740-30-4Cholinesterase (ChE)PhenanthreneBletilla striataAlzheimer's diseaseInhibitorinhibitorinhibit

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