2. Epigenetics Apoptosis
  3. Epigenetic Reader Domain Apoptosis
  4. BET-IN-20

BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage.

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BET-IN-20 Chemical Structure

BET-IN-20 Chemical Structure

CAS No. : 1300735-76-5

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BET-IN-20 Related Antibodies

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Description

BET-IN-20 (compound 10) is an inhibitor of BRD4 BD1 (IC50=1.9 nM) with anticancer activity. BET-IN-20 can promote acute myeloid leukemia (AML) cell apoptosis and arrest the cell cycle in the G0/G1 phase. BET-IN-20 also inhibits c-Myc and CDK6 and enhances PARP cleavage[1].

IC50 & Target

IC50: 1.9 nM (BRD4 BD1)[1]
Molecular Weight

412.48

Formula

C25H24N4O2
CAS No.
SMILES

C[C@H](C1=CC=CC=C1)N2C(C3=C4)=C(N=C2C)C=NC3=CC(C5=C(C)ON=C5C)=C4OC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BET-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BET-IN-201300735-76-5Epigenetic Reader DomainApoptosisacute myelogenous leukemiaAMLInhibitorinhibitorinhibit

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HY-149735
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