1. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  2. FAAH Cannabinoid Receptor
  3. CB2R/FAAH modulator-2

CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection.

For research use only. We do not sell to patients.

CB2R/FAAH modulator-2 Chemical Structure

CB2R/FAAH modulator-2 Chemical Structure

CAS No. : 2876918-68-0

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Description

CB2R/FAAH modulator-2 (compound 26) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-2 are 10.8 and 152.9 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].

IC50 & Target[1]

CB1

152.9 nM (Ki)

CB2

10.8 nM (Ki)

In Vitro

CB2R/FAAH modulator-2 (compound 26)(10 μM) reduces the production of the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β and IL6 in unstimulated monocytes and macrophages[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.52

Formula

C24H33NO2

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(OCC2CCCCC2)C=CC=C1)NC3(C4)C[C@H]5C[C@@H]4C[C@H](C5)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CB2R/FAAH modulator-2
Cat. No.:
HY-152253
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